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保护PC12神经元细胞免受活性氧介导的细胞凋亡所诱导的氧化应激。

Protects PC12 Neuronal Cells from Oxidative Stress Induced by ROS-Mediated Apoptosis.

作者信息

Lee Ji Yeon, Park Jeong-Yong, Kim Dong Hwi, Kim Hyung Don, Ji Yun-Jeong, Seo Kyung Hye

机构信息

Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Eumsung 27709, Republic of Korea.

Department of Food Science and Biotechnology, Chungbuk National University, Chungbuk 28644, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2020 Jan 6;2020:3945194. doi: 10.1155/2020/3945194. eCollection 2020.

DOI:10.1155/2020/3945194
PMID:31998396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6970001/
Abstract

Reactive oxygen species (ROS), associated with oxidative stress, are involved in many biological processes such as apoptosis, necrosis, and autophagy. Oxidative stress might induce neuronal damage via ROS generation, causing neurodegenerative diseases. (EA) has antioxidant properties and could protect neurons from oxidative stress. In this study, we investigated the protective effect of the aerial parts (EAA) and flowers (EAF) from EA on ROS-mediated apoptosis in pheochromocytoma 12 cells. We quantified 18 types of phenolic compounds using high-performance liquid chromatography. Pretreatment of the cells with EAA and EAF attenuated ROS generation and induced the expression of antioxidant enzymes such as superoxide dismutase 2, catalase, and glutathione peroxidase. In addition, EAF reduced the expression of apoptotic proteins such as Bax/Bcl-xL, caspase-3, and caspase-8 to a greater extent than that with EAA. These results suggested that the protective effect of EAF against oxidative stress-induced apoptosis might be due to the prevention of ROS generation mediated by oxidative enzymes.

摘要

活性氧（ROS）与氧化应激相关，参与许多生物过程，如细胞凋亡、坏死和自噬。氧化应激可能通过ROS的产生诱导神经元损伤，导致神经退行性疾病。刺蒺藜（EA）具有抗氧化特性，可以保护神经元免受氧化应激的影响。在本研究中，我们研究了刺蒺藜地上部分（EAA）和花（EAF）对嗜铬细胞瘤12细胞中ROS介导的细胞凋亡的保护作用。我们使用高效液相色谱法对18种酚类化合物进行了定量。用EAA和EAF预处理细胞可减弱ROS的产生，并诱导抗氧化酶如超氧化物歧化酶2、过氧化氢酶和谷胱甘肽过氧化物酶的表达。此外，EAF比EAA更能降低凋亡蛋白如Bax/Bcl-xL、半胱天冬酶-3和半胱天冬酶-8的表达。这些结果表明，EAF对氧化应激诱导的细胞凋亡的保护作用可能是由于预防了氧化酶介导的ROS产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/5eec9c62e834/ECAM2020-3945194.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/1111d85a7577/ECAM2020-3945194.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/d8f083557c14/ECAM2020-3945194.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/5eec9c62e834/ECAM2020-3945194.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/1111d85a7577/ECAM2020-3945194.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/d8f083557c14/ECAM2020-3945194.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7bb/6970001/5eec9c62e834/ECAM2020-3945194.003.jpg

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