Mohan Divya, Benson Victoria S, Allinder Matthew, Galwey Nicholas, Bolton Charlotte E, Cockcroft John R, MacNee William, Wilkinson Ian B, Tal-Singer Ruth, Polkey Michael I
Medical Innovation, Value Evidence and Outcomes, GlaxoSmithKline, Collegeville, Pennsylvania.
Epidemiology, Value Evidence and Outcomes, GlaxoSmithKline, Middlesex, United Kingdom.
Chronic Obstr Pulm Dis. 2020 Jan;7(1):13-25. doi: 10.15326/jcopdf.7.1.2019.0144.
To identify phenotypic factors associated with the Short Physical Performance Battery (SPPB) and its individual sub-tests: standing balance, 4‑meter gait speed (4mGS) and 5-repetition sit-to-stand (5STS).
The Evaluation of the Role of Inflammation in non-pulmonary disease manifestations in Chronic Airways disease (ERICA) study recruited adult participants with stable chronic obstructive pulmonary disease (COPD). Proportional odds models identified factors associated with the SPPB, and a principal component analysis (PCA) evaluated how much SPPB variance was explainable by each of its 3 sub-tests.
Of 729 enrolled participants, 717 (60% male, mean age 67 years) had full SPPB data. Overall, 76% of patients had some evidence of functional limitations (SPPB total score < 12). Scores < 4 were observed in 71%, 31%, and 22% of participants for the 5STS, 4mGS, and balance sub-tests, respectively. A longer 6-minute walk test and greater quadriceps maximal voluntary contraction decreased the odds of being in a lower score category for SPPB total score and for all 3 sub-tests. Aging, self-reported hypertension and higher dyspnea increased the odds, and being married decreased the odds of being in a lower category for total score. All sub-tests contributed equally to total score.
Each of the 3 sub-tests contributed independent information to the SPPB, demonstrating their usefulness for assessing COPD when considered together rather than individually. The 5STS sub-test had the greatest variation in scores and may thus have the best discriminatory power for clinical COPD studies of lower limb performance where only one SPPB test is feasible.
确定与简短体能状况量表（SPPB）及其各个子测试相关的表型因素，这些子测试包括站立平衡、4米步行速度（4mGS）和5次起坐试验（5STS）。
慢性气道疾病炎症在非肺部疾病表现中的作用评估（ERICA）研究招募了患有稳定慢性阻塞性肺疾病（COPD）的成年参与者。比例优势模型确定了与SPPB相关的因素，主成分分析（PCA）评估了其3个子测试中每个子测试对SPPB方差的解释程度。
在729名登记参与者中，717名（60%为男性，平均年龄67岁）有完整的SPPB数据。总体而言，76%的患者有功能受限的某些证据（SPPB总分<12）。在5STS、4mGS和平衡子测试中，分别有71%、31%和22%的参与者得分<4。6分钟步行试验时间越长以及股四头肌最大自主收缩力越大，SPPB总分及所有3个子测试处于较低分数类别的几率降低。年龄增长、自我报告的高血压和更高的呼吸困难几率增加，而已婚则降低了总分处于较低类别的几率。所有子测试对总分的贡献相同。
3个子测试中的每一个都为SPPB提供了独立信息，表明它们一起考虑而非单独考虑时对评估COPD有用。5STS子测试的分数变化最大，因此对于仅进行一项SPPB测试可行的下肢功能临床COPD研究可能具有最佳鉴别力。
