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与中度慢性阻塞性肺疾病相关的肌少症的功能测试。

Functional tests associated with sarcopenia in moderate chronic obstructive pulmonary disease.

机构信息

Programa Multicêntrico De Pós-Graduação Em Ciências Fisiológicas, Sociedade Brasileira De Fisiologia, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Diamantina, Brasil.

Laboratório De Inflamação E Metabolismo - LIM, CIPq Saúde, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Diamantina, Brasil.

出版信息

Expert Rev Respir Med. 2021 Apr;15(4):569-576. doi: 10.1080/17476348.2021.1850276. Epub 2020 Dec 6.

DOI:10.1080/17476348.2021.1850276
PMID:33197358
Abstract

: To evaluate the association of physical and functional measures with sarcopenia in moderate chronic obstructive pulmonary disease (COPD) and to establish cutoff points for sarcopenia screening.: The study included COPD with and without sarcopenia, of both sexes who were over 50 years old. Participants were assessed for lung function, body composition, grip strength, Short Physical Performance Battery (SPPB), 5-repetition, 10-repetition and 30-s sit-to-stand tests (5STS, 10STS, and 30STS, respectively). In addition, 6-min walking test, respiratory muscular strength, and physical activity level were tested.: The study had 35 participants, 24 men (68.6%) and moderate COPD (51.4%). COPD-sarcopenia showed lower values in lean mass, body fat and body mass alongside lower performance in 10 and 30 STS tests, SPPB and gait speed compared to non-sarcopenic group. The cutoff points with better sensitivity and specificity to identify sarcopenia were 10.88 and 34.14 s, 15 repetitions, and 10 points in the 5STS, 10STS, 30STS, and SPPB, respectively. The comparison of the receiver operating curves evidenced no differences between the functional tests. Only 30STS and SPPB showed acceptable discriminatory power.: Functional tests, especially 30STS and SPPB, are simple and affordable tools for screening sarcopenia in COPD with moderate obstruction.

摘要

: 目的:评估身体和功能测量指标与中重度慢性阻塞性肺疾病(COPD)患者肌肉减少症的相关性,并确定肌肉减少症筛查的切点。: 研究纳入了伴有或不伴有肌肉减少症的中重度 COPD 患者,年龄均在 50 岁以上。对参与者进行肺功能、身体成分、握力、简易体能状况量表(SPPB)、5 次重复坐立试验(5STS)、10 次重复坐立试验(10STS)和 30 秒坐立-站立试验(30STS)评估。此外,还对 6 分钟步行试验、呼吸肌力量和身体活动水平进行了测试。: 研究共纳入 35 名参与者,其中 24 名男性(68.6%),患有中度 COPD(51.4%)。COPD 肌肉减少症组的瘦体重、体脂肪和体重较低,与非肌肉减少症组相比,10STS 和 30STS 测试、SPPB 和步速的表现也较低。在敏感性和特异性方面,识别肌肉减少症的最佳截点值分别为 10.88 和 34.14 秒、15 次重复和 5STS、10STS、30STS 和 SPPB 中的 10 分。受试者工作特征曲线比较表明,各功能测试之间无差异。仅 30STS 和 SPPB 显示出可接受的鉴别能力。: 功能性测试,尤其是 30STS 和 SPPB,是一种简单、经济的中重度阻塞性 COPD 患者肌肉减少症筛查工具。

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