戈德布拉特I型肾血管性高血压中下丘脑去甲肾上腺素生物合成增强。
Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension.
作者信息
Dequattro V, Eide I, Myers M R, Eide K, Kolloch R, Whigham H
出版信息
Clin Sci Mol Med Suppl. 1978 Dec;4:109s-111s. doi: 10.1042/cs055109s.
PMID:32000
Abstract
- Hypertension was induced in rats by renal artery clip with the contralateral kidney removed (Goldblatt I) or left intact (Goldblatt II). 2. Plasma noradrenaline was increased 62% in the Goldblatt I animals after 3 weeks. 3. Hypothalamic tyrosine hydroxylase and dopamine beta-hydroxylase activities, and the concentration of noradrenaline were increased in the Goldblatt I animals after 3 weeks. 4. Enhanced hypothalamic noradrenaline synthesis may be a pathogenic factor in Goldblatt I renovascular hypertension.
摘要
- 通过切除对侧肾脏（戈德布拉特I型）或使其保持完整（戈德布拉特II型），用肾动脉夹在大鼠中诱发高血压。2. 3周后，戈德布拉特I型动物的血浆去甲肾上腺素增加了62%。3. 3周后，戈德布拉特I型动物的下丘脑酪氨酸羟化酶和多巴胺β-羟化酶活性以及去甲肾上腺素浓度增加。4. 下丘脑去甲肾上腺素合成增强可能是戈德布拉特I型肾血管性高血压的致病因素。
相似文献
1
Enhanced hypothalamic noradrenaline biosynthesis in Goldblatt I renovascular hypertension.戈德布拉特I型肾血管性高血压中下丘脑去甲肾上腺素生物合成增强。
Clin Sci Mol Med Suppl. 1978 Dec;4:109s-111s. doi: 10.1042/cs055109s.
2
Increased hypothalamic noradrenergic activity in one-kidney, one-clip renovascular hypertensive rats.
J Cardiovasc Pharmacol. 1980 Nov-Dec;2(6):833-41. doi: 10.1097/00005344-198011000-00012.
3
Plasma noradrenaline concentrations in experimental renovascular hypertension in the rat.大鼠实验性肾血管性高血压中的血浆去甲肾上腺素浓度
Clin Sci Mol Med. 1977 May;52(5):477-83. doi: 10.1042/cs0520477.
4
Decrease in hypothalamic norepinephrine content following renal denervation in the one-kidney, one clip Goldblatt hypertensive rat.
Hypertension. 1982 May-Jun;4(3):369-73. doi: 10.1161/01.hyp.4.3.369.
5
Brain catecholamines and catecholamine-synthesizing enzymes in renovascular hypertension in the rat.大鼠肾血管性高血压中的脑儿茶酚胺和儿茶酚胺合成酶
Clin Sci Mol Med Suppl. 1978 Dec;4:101s-103s. doi: 10.1042/cs055101s.
6
Norepinephrine turnover in the cardiovascular tissues and brain stem of the rabbit during development of one-kidney and two-kidney Goldblatt hypertension.
Hypertension. 1982 Mar-Apr;4(2):272-8. doi: 10.1161/01.hyp.4.2.272.
7
Plasma noradrenaline and renovascular hypertension in the rat.大鼠血浆去甲肾上腺素与肾血管性高血压
Clin Sci Mol Med Suppl. 1976 Dec;3:439S-442S. doi: 10.1042/cs051439s.
8
Noradrenaline concentration and turnover in nuclei of the hyothalamus and the medulla oblongata at two stages in the development of renal hypertension in the rat.
Brain Res. 1980 Oct 6;198(2):411-17. doi: 10.1016/0006-8993(80)90754-4.
9
Importance of the renal nerves in established two-kidney, one clip Goldblatt hypertension.
Hypertension. 1982 May-Jun;4(3 Pt 2):166-74.
10
Sodium sensitivity and its role in the maintenance of high blood pressure in two-kidney, one-clip renovascular hypertension after removal of the clipped kidney in rats.
Minerva Urol Nefrol. 2010 Sep;62(3):225-9.
Zotero 插件