Hu Xiaolei, Zhang Hengyan, Song Yuan, Yang Qingqing, Zhuang Langen, Jin Guoxi, Zhang Shirong, Sun Weihua, Shi Zhaoming
Department of Endocrinology.
Laboratory of the Endocrinology Department, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Medicine (Baltimore). 2020 Jan;99(5):e18940. doi: 10.1097/MD.0000000000018940.
Soluble suppression of tumorigenicity 2 (sST2) is a free form of membrane-bound ST2, which is a member of the interleukin-1 receptor family. Previous research has shown that sST2 is associated with diabetes, but cardiovascular risk factors have not been established.To analyze the relationship between sST2 and carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM).After screening, a total of 118 subjects with T2DM were divided into 2 groups according to the measurement of CIMT (normal CIMT (NCIMT), n = 58; abnormal CIMT (ACIMT), n = 60), and 60 healthy subjects (normal control (NC), n = 60) were recruited in this study. CIMT was measured by a color Doppler ultrasound, and sST2 and other metabolic parameters were measured as well.The median concentration of sST2 was elevated in the ACIMT group (31.30 ng/ml) compared with the NCIMT group (28.29 ng/ml, P < .01) and the NC group (20.15 ng/ml, P < .01). After adjustment for age and sex, log sST2 was strongly associated with smoking history (β = 0.197, 95% CI, 0.084-0.311, P < .01), FPG level (β = 0.302, 95% CI, 0.162-0.442, P < .01) and HbA1c level (β = 0.296, 95% CI, 0.165-0.426, P < .01) and negatively correlated with HDL level (β = -0.153, 95% CI, -0.259 to -0.046, P < .01). Furthermore, sST2 level was a risk factor for increased CIMT in patients with T2DM.Increased sST2 level not only was associated with indicators of glucose and lipid metabolism but also was a risk factor for increased CIMT in patients with T2DM. Thus, sST2 may be a potential novel marker to assess the progression of diabetic macrovascular complications.
可溶性致瘤性抑制因子2（sST2）是膜结合型ST2的游离形式，ST2是白细胞介素-1受体家族的成员。以往研究表明，sST2与糖尿病有关，但尚未明确其与心血管危险因素的关系。分析2型糖尿病（T2DM）患者中sST2与颈动脉内膜中层厚度（CIMT）之间的关系。经过筛选，根据CIMT测量结果将118例T2DM患者分为2组（正常CIMT（NCIMT）组，n = 58；异常CIMT（ACIMT）组，n = 60），并招募60例健康受试者作为正常对照组（NC组，n = 60）。采用彩色多普勒超声测量CIMT，并检测sST2及其他代谢参数。与NCIMT组（28.29 ng/ml，P <.01）和NC组（20.15 ng/ml，P <.01）相比，ACIMT组sST2的中位浓度升高（31.30 ng/ml）。在调整年龄和性别后，log sST2与吸烟史（β = 0.197，95%CI，0.084 - 0.311，P <.01）、空腹血糖（FPG）水平（β = 0.302，95%CI，0.162 - 0.442，P <.01）和糖化血红蛋白（HbA1c）水平（β = 0.296，95%CI，0.165 - 0.426，P <.01）密切相关，与高密度脂蛋白（HDL）水平呈负相关（β = -0.153，95%CI，-0.259至-0.046，P <.01）。此外，sST2水平是T2DM患者CIMT增加的危险因素。sST2水平升高不仅与糖脂代谢指标相关，也是T2DM患者CIMT增加的危险因素。因此，sST2可能是评估糖尿病大血管并发症进展的潜在新型标志物。
