Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand Medical School, 7 York Road, Parktown, Johannesburg, 2193, South Africa.
BMC Cardiovasc Disord. 2020 Jan 30;20(1):35. doi: 10.1186/s12872-019-01319-w.
Although, in-part through an impact on left ventricular mass (LVM), resistin (an adipokine) may contribute to heart failure, whether this is explained by the adverse effects of resistin on aortic stiffness and renal function is unknown.
Relationships between circulating resistin concentrations and LVM index (LVMI), and LVM beyond that predicted by stroke work (inappropriate LVM [LVM]) (echocardiography) were determined in 647 randomly selected community participants, and in regression analysis, the extent to which these relations could be explained by aortic pulse wave velocity (PWV) or estimated glomerular filtration rate (eGFR) was evaluated.
Independent of confounders, resistin concentrations were independently associated with LVMI, LVM, LV hypertrophy (LVH), PWV and eGFR. Furthermore, independent of confounders, LVMI, LVM and LVH were independently associated with PWV and eGFR. However, adjustments for either PWV or eGFR failed to modify the relationships between resistin concentrations and LVMI, LVM or LVH. Moreover, in multivariate regression analysis neither PWV nor eGFR significantly modified the contribution of resistin to LVM or LVMI.
Independent relationships between circulating concentrations of the adipocytokine resistin and LVM are not explained by the impact of resistin on ventricular-vascular coupling or renal dysfunction. Resistin's effects on LVM are therefore likely to be through direct actions on the myocardium.
尽管抵抗素（一种脂肪细胞因子）可能通过影响左心室质量（LVM）导致心力衰竭，但抵抗素对主动脉僵硬和肾功能的不良影响是否对此有解释作用尚不清楚。
在 647 名随机选择的社区参与者中，确定了循环抵抗素浓度与 LVM 指数（LVMI）和超越由中风工作量预测的 LVM（不当 LVM [LVM]）（超声心动图）之间的关系，并在回归分析中，评估了这些关系在多大程度上可以通过主动脉脉搏波速度（PWV）或估算肾小球滤过率（eGFR）来解释。
独立于混杂因素，抵抗素浓度与 LVMI、LVM、LV 肥厚（LVH）、PWV 和 eGFR 独立相关。此外，独立于混杂因素，LVMI、LVM 和 LVH 与 PWV 和 eGFR 独立相关。然而，调整 PWV 或 eGFR 并不能改变抵抗素浓度与 LVMI、LVM 或 LVH 之间的关系。此外，多元回归分析表明，PWV 或 eGFR 均不能显著改变抵抗素对 LVM 或 LVMI 的贡献。
循环抵抗素浓度与 LVM 之间独立的关系不能用抵抗素对心室-血管偶联或肾功能障碍的影响来解释。因此，抵抗素对 LVM 的影响可能是通过直接作用于心肌。
