耶尔森菌诱导的反应性关节炎实验小鼠模型
An experimental mouse model of Yersinia-induced reactive arthritis.
作者信息
Yong Z, Hill J L, Hirofuji T, Mander M, Yu D T
机构信息
Department of Medicine, University of California Los Angeles 90024.
出版信息
Microb Pathog. 1988 Apr;4(4):305-10. doi: 10.1016/0882-4010(88)90091-5.
PMID:3200165
Abstract
An experimental animal model of Yersinia-induced arthritis was successfully developed in mice using Yersinia enterocolitica WA. In order for the Yersinia to induce arthritis the strain had to be cured of plasmid. The arthritis-susceptible mouse strains were DBA/2 and BDF1. C57B1/6, Balb/c, CBA and DBA/1 were arthritis-resistant. Both the dose of bacteria and the route of administration were critical.
摘要
利用小肠结肠炎耶尔森菌WA在小鼠中成功建立了耶尔森菌诱导性关节炎的实验动物模型。为了使耶尔森菌诱导关节炎，该菌株必须去除质粒。易患关节炎的小鼠品系为DBA/2和BDF1。C57B1/6、Balb/c、CBA和DBA/1对关节炎具有抗性。细菌剂量和给药途径都至关重要。
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