EphA2在宿主抵御口咽念珠菌病中的作用。
Role of EphA2 in host defense against oro-pharyngeal candidiasis.
作者信息
Olsen Ingar
机构信息
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
出版信息
J Oral Microbiol. 2020 Jan 9;12(1):1711619. doi: 10.1080/20002297.2020.1711619. eCollection 2020.
Abstract
Oral defense should be able to sense the burden of, and distinguish between fungal commensals and pathogens, so that an adequate inflammatory response can be set up. Recently, Ephrin type-A receptor 2 (EphA2) was identified on oral epithelial cells and neutrophils that recognizes and induces adaptive protective host responses against this organism. The studies have increased our knowledge of how epithelial cells and neutrophils contribute to host defense against oral yeast infection.
摘要
口腔防御应该能够感知真菌共生菌和病原体的负荷，并加以区分，从而引发适当的炎症反应。最近，在口腔上皮细胞和中性粒细胞上发现了Ephrin A型受体2（EphA2），它能够识别并诱导宿主对这种生物体产生适应性保护反应。这些研究增加了我们对上皮细胞和中性粒细胞如何参与宿主抵抗口腔酵母菌感染防御机制的认识。
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