Grandidge Lisa, Chotiyarnwong Chayaporn, White Sean, Denning Jessica, Nair Krishnan Padmakumari Sivaraman
Princess Royal Spinal Injuries and Neurorehabilitation Centre, Northern General Hospital, Herries Road, Sheffield, UK.
Department of Neuroscience, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Mult Scler J Exp Transl Clin. 2020 Jan 14;6(1):2055217319900907. doi: 10.1177/2055217319900907. eCollection 2020 Jan-Mar.
Around a third of people with multiple sclerosis (MS) experience dysphagia. There is a need for disease-specific information on survival following placement of gastrostomy tube in people with MS.
We aimed to study survival following gastrostomy in patients with MS.
We reviewed medical records, home enteral feeding database and death certificates of people with MS who had gastrostomy from 2005 to 2017. Cox regression analysis was performed to identify independent predictors associated with mortality after gastrostomy.
Median survival of 53 patients with MS after gastrostomy was 21.73 months. Median duration of hospital stay after gastrostomy was 14 days (IQR 5.25, 51.5). Survival at 30 days, 3 months, 1, 2, 5 and 10 years were 100% (53/53), 98.1% (52/53), 81.1% (43/53), 54.7% (29/53), 22.4% (11/49) and 6.8% (3/44), respectively. Of 53 patients, 24 died due to respiratory tract infection. Patients who had gastrostomy tube before 50 years of age survived longer (median 28.48 months) compared with those who had the gastrostomy after age 50 years (median 17.51 months) ( = 0.040).
Around 54% of patients with MS survived two or more years following gastrostomy. Younger patients had better survival. The most frequent cause of death was respiratory infection.
约三分之一的多发性硬化症（MS）患者存在吞咽困难。需要有关MS患者胃造口管置入后生存情况的疾病特异性信息。
我们旨在研究MS患者胃造口术后的生存情况。
我们回顾了2005年至2017年期间接受胃造口术的MS患者的病历、家庭肠内喂养数据库和死亡证明。进行Cox回归分析以确定与胃造口术后死亡率相关的独立预测因素。
53例MS患者胃造口术后的中位生存期为21.73个月。胃造口术后的中位住院时间为14天（四分位间距5.25，51.5）。30天、3个月、1年、2年、5年和10年的生存率分别为100%（53/53）、98.1%（52/53）、81.1%（43/53）、54.7%（29/53）、22.4%（11/49）和6.8%（3/44）。53例患者中，24例死于呼吸道感染。50岁之前接受胃造口管置入的患者比50岁之后接受胃造口术的患者生存期更长（中位生存期分别为28.48个月和17.51个月）（P = 0.040）。
约54%的MS患者在胃造口术后存活两年或更长时间。年轻患者的生存率更高。最常见的死亡原因是呼吸道感染。
