钙网蛋白武装自然杀伤细胞对抗白血病。
Calreticulin arms NK cells against leukemia.
作者信息
Fucikova Jitka, Kline Justin P, Galluzzi Lorenzo, Spisek Radek
机构信息
Sotio, Prague, Czech Republic.
Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.
出版信息
Oncoimmunology. 2019 Oct 9;9(1):1671763. doi: 10.1080/2162402X.2019.1671763. eCollection 2020.
Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure on leukemic blasts also supports innate anticancer immunity by natural killer (NK) cells via an indirect mechanism relying on myeloid CD11cCD14 cells.
在因治疗而死亡的癌细胞表面暴露的钙网蛋白（CALR）会传递强大的吞噬信号，这些信号有助于激活适应性抗癌免疫反应。我们团队最近的数据表明，白血病原始细胞上自发的CALR暴露也通过一种依赖于髓样CD11cCD14细胞的间接机制，支持自然杀伤（NK）细胞的先天性抗癌免疫。
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