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钙网蛋白武装自然杀伤细胞对抗白血病。

Calreticulin arms NK cells against leukemia.

作者信息

Fucikova Jitka, Kline Justin P, Galluzzi Lorenzo, Spisek Radek

机构信息

Sotio, Prague, Czech Republic.

Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic.

出版信息

Oncoimmunology. 2019 Oct 9;9(1):1671763. doi: 10.1080/2162402X.2019.1671763. eCollection 2020.

DOI:10.1080/2162402X.2019.1671763
PMID:32002282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6959451/
Abstract

Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure on leukemic blasts also supports innate anticancer immunity by natural killer (NK) cells via an indirect mechanism relying on myeloid CD11cCD14 cells.

摘要

在因治疗而死亡的癌细胞表面暴露的钙网蛋白（CALR）会传递强大的吞噬信号，这些信号有助于激活适应性抗癌免疫反应。我们团队最近的数据表明，白血病原始细胞上自发的CALR暴露也通过一种依赖于髓样CD11cCD14细胞的间接机制，支持自然杀伤（NK）细胞的先天性抗癌免疫。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1578/6959451/421236afb7f9/koni-09-01-1671763-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1578/6959451/421236afb7f9/koni-09-01-1671763-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1578/6959451/421236afb7f9/koni-09-01-1671763-g001.jpg

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本文引用的文献

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Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients.恶性白血病细胞表面钙网织蛋白的暴露与急性髓系白血病患者自然杀伤细胞介导的细胞毒性增强相关。
Haematologica. 2020 Jul;105(7):1868-1878. doi: 10.3324/haematol.2019.223933. Epub 2019 Oct 3.
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The hallmarks of successful anticancer immunotherapy.成功的抗癌免疫疗法的特征。
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Natural killer cells and other innate lymphoid cells in cancer.
Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockade.
常规两性霉素 B 可诱导白血病细胞发生免疫原性细胞死亡，介导吞噬细胞的免疫刺激作用，并与 PD-L1 阻断协同作用。
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Immune Cell-Derived Extracellular Vesicles - New Strategies in Cancer Immunotherapy.免疫细胞衍生的细胞外囊泡——癌症免疫治疗的新策略。
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Trial watch: intratumoral immunotherapy.试验观察：肿瘤内免疫疗法。
Oncoimmunology. 2021 Oct 15;10(1):1984677. doi: 10.1080/2162402X.2021.1984677. eCollection 2021.
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Leveraging NKG2D Ligands in Immuno-Oncology.利用免疫肿瘤学中的 NKG2D 配体。
Front Immunol. 2021 Jul 29;12:713158. doi: 10.3389/fimmu.2021.713158. eCollection 2021.
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TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patients.TIM-3 水平与增强的 NK 细胞细胞毒性和改善 AML 患者的临床结局相关。
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