钙网织蛋白暴露调控固有免疫监视。
Calreticulin exposure orchestrates innate immunosurveillance.
机构信息
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
出版信息
Cancer Cell. 2023 Jun 12;41(6):1014-1016. doi: 10.1016/j.ccell.2023.04.015. Epub 2023 May 18.
Calreticulin (CALR) exposure on the cell surface is known to deliver robust pro-phagocytic signals to myeloid cells. In Nature, Sen Santara et al. demonstrate that surface-exposed CALR also operates as an endogenous activator of natural killer (NK) cells. Collectively, these findings suggest that CALR exposure orchestrates multiple facets of innate immunosurveillance.
钙网织蛋白（CALR）在细胞表面的暴露被认为向髓样细胞传递强大的促吞噬信号。在《自然》杂志上，Sen Santara 等人证明，表面暴露的 CALR 也作为自然杀伤（NK）细胞的内源性激活剂发挥作用。总的来说，这些发现表明 CALR 的暴露协调了先天免疫监视的多个方面。
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