Ophthalmology Department, CHU Nantes, Nantes, France.
Centre de Recherche en Transplantation et Immunologie, Inserm, Université de Nantes, Nantes, France.
Methods Mol Biol. 2020;2110:245-251. doi: 10.1007/978-1-0716-0255-3_16.
Corneal transplantation for the treatment of corneal blindness is challenging in many countries due to the shortage of graft procurement. Xenocorneal transplantation is an interesting alternative to explore despite immunologic rejection, which mainly involves endothelial cells. As anterior lamellar keratoplasty, when indicated, shows less immunologic reaction, we developed and describe below a pig-to-non-human-primate model of anterior lamellar corneal xenograft. This model can be used to assess the efficacy of corneas from genetically modified pigs.
角膜移植治疗角膜盲在许多国家都具有挑战性，因为供体获取困难。尽管存在免疫排斥反应，主要涉及内皮细胞，但异种角膜移植是一种很有前途的探索方法。由于前板层角膜移植在适应证下显示出较低的免疫反应，因此我们开发并描述了下面的猪到非人类灵长类动物前板层角膜异种移植物模型。该模型可用于评估基因修饰猪供体角膜的功效。
