饮食失调中脑脊液肽YY免疫反应性
Cerebrospinal fluid peptide YY immunoreactivity in eating disorders.
作者信息
Berrettini W H, Kaye W H, Gwirtsman H, Allbright A
机构信息
Clinical Neurogenetics Branch, NIHMH, Bethesda, Md.
出版信息
Neuropsychobiology. 1988;19(3):121-4. doi: 10.1159/000118446.
Peptide YY (PYY), a recently discovered peptide, is a potent stimulant of eating behavior in rats. We developed a radioimmunoassay for PYY and measured cerebrospinal fluid (CSF) levels in subjects with anorexia nervosa, bulimia and matched normal controls. Bulimics who had abstained from bingeing for 30 days showed a dramatic increase in CSF PYY levels compared to normal values (p less than 0.001) or their own values when actively bingeing (p less than 0.01, paired t test). No differences were seen for anorexia nervosa. These results suggest that bulimic behavior may correct a central nervous system abnormality in PYY.
肽YY（PYY）是最近发现的一种肽，是大鼠进食行为的强效刺激物。我们开发了一种用于检测PYY的放射免疫分析法，并测量了神经性厌食症、贪食症患者及配对正常对照者的脑脊液（CSF）水平。与正常水平相比（p<0.001），或与他们在积极 bingeing 时自身的水平相比（p<0.01，配对t检验），已经30天未 bingeing 的贪食症患者脑脊液PYY水平显著升高。神经性厌食症患者未观察到差异。这些结果表明，贪食行为可能纠正了中枢神经系统中PYY的异常。 （注：“bingeing”常见释义为“暴饮暴食”，这里保留英文未翻译，因为原文未给出更准确的中文释义）
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