长期康复的饮食失调患者体内的瘦素、神经肽Y和肽YY 。
Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients.
作者信息
Gendall K A, Kaye W H, Altemus M, McConaha C W, La Via M C
机构信息
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213-2593, USA.
出版信息
Biol Psychiatry. 1999 Jul 15;46(2):292-9. doi: 10.1016/s0006-3223(98)00292-3.
BACKGROUND
Disturbances of leptin, neuropeptide Y (NPY), and peptide YY (PYY) have been found in women who are ill with anorexia or bulimia nervosa. It is not certain whether peptide disturbances are cause or consequence of eating disorders.
METHODS
Plasma leptin and cerebrospinal fluid leptin, NPY, and PYY concentrations were measured in women who were recovered from anorexia or bulimia nervosa to determine whether alterations persisted after recovery.
RESULTS
NPY, PYY, and leptin concentrations were similar across all diagnostic groups.
CONCLUSIONS
Alterations in NPY, PYY, and serum leptin concentrations are probably secondary to pathological eating behaviors. Alterations of these peptides are unlikely to be trait-related disturbances that contribute to the etiology of eating disorders.
背景
在患有神经性厌食症或神经性贪食症的女性中发现了瘦素、神经肽Y（NPY）和肽YY（PYY）的紊乱情况。尚不确定肽紊乱是饮食失调的原因还是结果。
方法
对从神经性厌食症或神经性贪食症中康复的女性测量其血浆瘦素、脑脊液瘦素、NPY和PYY浓度，以确定康复后这些改变是否持续存在。
结果
所有诊断组的NPY、PYY和瘦素浓度相似。
结论
NPY、PYY和血清瘦素浓度的改变可能继发于病理性饮食行为。这些肽的改变不太可能是与特质相关的紊乱，从而导致饮食失调的病因。
Zotero 插件