人脑脊液中甘丙肽免疫反应性：饮食失调与阿尔茨海默病的研究

Galanin immunoreactivity in human CSF: studies in eating disorders and Alzheimer's disease.

作者信息

Berrettini W H, Kaye W H, Sunderland T, May C, Gwirtsman H E, Mellow A, Albright A

机构信息

National Institute of Mental Health, Bethesda, Md.

出版信息

Neuropsychobiology. 1988;19(2):64-8. doi: 10.1159/000118436.

DOI:10.1159/000118436

PMID:2465504

Abstract

Galanin is a peptide which stimulates feeding behavior in animals and is found within those basal forebrain cholinergic neurons which degenerate in Alzheimer's disease. Galanin was measured in cerebrospinal fluid (CSF) by radioimmunoassay. The nature of the immunoreactivity was characterized chromatographically as authentic galanin. CSF galanin levels were determined in subjects with Alzheimer's disease, involutional depression, anorexia nervosa and bulimia. No differences between any diagnostic group and age and sex-matched controls were found.

摘要

甘丙肽是一种能刺激动物进食行为的肽，存在于阿尔茨海默病中会退化的基底前脑胆碱能神经元内。通过放射免疫分析法测定脑脊液（CSF）中的甘丙肽。免疫反应性的性质经色谱分析确定为真实的甘丙肽。测定了阿尔茨海默病、更年期抑郁症、神经性厌食症和贪食症患者脑脊液中的甘丙肽水平。未发现任何诊断组与年龄和性别匹配的对照组之间存在差异。