Department of Orthopaedic Surgery, Rothman Institute, Thomas Jefferson University, Philadelphia, PA.
Spine (Phila Pa 1976). 2020 Jun 15;45(12):798-803. doi: 10.1097/BRS.0000000000003399.
Retrospective cohort review.
The objective of this study was to identify depression using the Mental Component Score (MCS-12) of the Short Form-12 (SF-12) survey and to correlate with patient outcomes.
The impact of preexisting depressive symptoms on health-care related quality of life (HRQOL) outcomes following lumbar spine fusion is not well understood.
Patients undergoing lumbar fusion between one to three levels at a single center, academic hospital were retrospectively identified. Patients under the age of 18 years and those undergoing surgery for infection, trauma, tumor, or revision, and less than 1-year follow-up were excluded. Patients with depressive symptoms were identified using an existing clinical diagnosis or a score of MCS-12 less than or equal to 45.6 on the preoperative SF-12 survey. Absolute HRQOL scores, the recovery ratio (RR) and the percent of patients achieving minimum clinically important difference (MCID) between groups were compared, and a multiple linear regression analysis was performed.
A total of 391 patients were included in the total cohort, with 123 (31.5%) patients reporting symptoms of depression based on MCS-12 and 268 (68.5%) without these symptoms. The low MCS-12 group was found to have significantly worse preoperative Oswestry disability index (ODI), visual analogue scale back pain (VAS Back) and visual analogue scale leg pain (VAS Leg) scores, and postoperative SF-12 physical component score (PCS-12), ODI, VAS Back, and VAS Leg pain scores (P < 0.05) than the non-depressed group. Finally, multiple linear regression analysis revealed preoperative depression to be a significant predictor of worse outcomes after lumbar fusion.
Patients with depressive symptoms, identified with an MCS-12 cutoff below 45.6, were found to have significantly greater disability in a variety of HRQOL domains at baseline and postoperative measurement, and demonstrated less improvement in all outcome domains included in the analysis compared with patients without depression. However, while the improvement was less, even the low MCS-12 cohort demonstrated statistically significant improvement in all HRQOL outcome measures after surgery.
回顾性队列研究。
本研究旨在使用 12 项简明健康量表(SF-12)的精神健康分量表(MCS-12)识别抑郁,并与患者结局相关联。
术前抑郁症状对腰椎融合术后与健康相关的生活质量(HRQOL)结局的影响尚不清楚。
在一家学术医院,我们对单一中心行 1 至 3 个节段腰椎融合术的患者进行了回顾性识别。排除年龄小于 18 岁、因感染、创伤、肿瘤或翻修而接受手术以及随访时间不足 1 年的患者。使用术前 SF-12 调查中存在的临床诊断或 MCS-12 评分低于或等于 45.6 来识别有抑郁症状的患者。比较两组之间的绝对 HRQOL 评分、恢复率(RR)和达到最小临床重要差异(MCID)的患者比例,并进行多元线性回归分析。
共有 391 例患者纳入总队列,其中 123 例(31.5%)患者根据 MCS-12 报告有抑郁症状,268 例(68.5%)患者无抑郁症状。低 MCS-12 组的术前 Oswestry 残疾指数(ODI)、视觉模拟量表腰痛(VAS 腰痛)和视觉模拟量表腿痛(VAS 腿痛)评分以及术后 SF-12 躯体成分评分(PCS-12)、ODI、VAS 腰痛和 VAS 腿痛评分明显更差(P<0.05)。最后,多元线性回归分析显示,术前抑郁是腰椎融合术后结局不佳的显著预测因素。
MCS-12 评分低于 45.6 的抑郁患者在基线和术后测量时,在各种 HRQOL 领域的残疾程度明显更高,与无抑郁患者相比,在所有纳入分析的结局领域的改善程度较小。然而,尽管改善程度较小,低 MCS-12 组在手术后所有 HRQOL 结局测量中仍显示出统计学显著的改善。
3 级。