Department of Neurology, Columbia University Medical Center, New York, New York, USA.
Curr Opin Clin Nutr Metab Care. 2020 Mar;23(2):68-75. doi: 10.1097/MCO.0000000000000634.
The purpose of this brief review is to gain an understanding on the multiple roles that lipids exert on the brain, and to highlight new ideas in the impact of lipid homeostasis in the regulation of synaptic transmission.
Recent data underline the crucial function of lipid homeostasis in maintaining neuronal function and synaptic plasticity. Moreover, new advances in analytical approaches to study lipid classes and species is opening a new door to understand and monitor how alterations in lipid pathways could shed new light into the pathogenesis of neurodegeneration.
Lipids are one of the most essential elements of the brain. However, our understanding of the role of lipids within the central nervous system is still largely unknown. Identifying the molecular mechanism (s) by which lipids can regulate neuronal transmission represents the next frontier in neuroscience, and a new challenge in our understanding of the brain and the mechanism(s) behind neurological disorders.
本篇简要综述的目的是了解脂质在大脑中发挥的多种作用，并强调脂质动态平衡在调节突触传递中的作用的新观点。
最近的数据强调了脂质动态平衡在维持神经元功能和突触可塑性中的关键作用。此外，分析方法的新进展可用于研究脂质类和脂质种类，这为了解和监测脂质途径的改变如何为神经退行性变的发病机制提供新的见解开辟了新的途径。
脂质是大脑中最重要的元素之一。 然而，我们对中枢神经系统中脂质作用的了解仍在很大程度上未知。确定脂质可以调节神经元传递的分子机制代表了神经科学的下一个前沿，也是我们对大脑和神经障碍背后机制的理解的新挑战。
