被动微波辐射测量在生物医学研究中的应用。

Passive microwave radiometry in biomedical studies.

机构信息

University of Edinburgh, UK; Okinawa Institute Science and Technology, Okinawa, Japan; Tianjin Institute of Industrial Biotechnology, Tianjin, China.

ARAGON GROUP INC.

出版信息

Drug Discov Today. 2020 Apr;25(4):757-763. doi: 10.1016/j.drudis.2020.01.016. Epub 2020 Jan 28.

DOI:10.1016/j.drudis.2020.01.016

PMID:32004473

Abstract

Passive microwave radiometry (MWR) measures natural emissions in the range 1-10GHz from proteins, cells, organs and the whole human body. The intensity of intrinsic emission is determined by biochemical and biophysical processes. The nature of this process is still not very well known. Infrared thermography (IRT) can detect emission several microns deep (skin temperature), whereas MWR allows detection of thermal abnormalities down to several centimeters (internal or deep temperature). MWR is noninvasive and inexpensive. It requires neither fluorescent nor radioactive labels, nor ionizing or other radiation. MWR can be used in early drug discovery as well as preclinical and clinical studies.

摘要

被动微波辐射测量法（MWR）测量 1-10GHz 范围内的蛋白质、细胞、器官和整个人体的自然发射。固有发射的强度由生化和生物物理过程决定。这个过程的性质还不是很清楚。红外热成像（IRT）可以探测几微米深的发射（皮肤温度），而 MWR 则可以探测到几厘米深的热异常（内部或深部温度）。MWR 是一种非侵入性和廉价的方法。它既不需要荧光或放射性标记物，也不需要电离或其他辐射。MWR 可用于早期药物发现以及临床前和临床研究。