Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Guangdong Huangcun Sports Training Center (Rehabilitation Center), Guangzhou, Guangdong, China.
Interdiscip Sci. 2020 Jun;12(2):131-144. doi: 10.1007/s12539-020-00359-7. Epub 2020 Jan 31.
Parkinson's disease (PD) is another major neurodegenerative disorder following Alzheimer's disease, which not only seriously reduces the survival in patients, affecting patient's quality of life, but also imposes a tremendous burden on families and even the whole society. It is urgent to find out effective drugs without side effects. The present study applied a creative approach called network pharmacology to explore the active compounds and therapeutic targets of Shaoyao-Gancao Decoction (SYGCD) for treating PD. We identified a total of 48 active compounds mediating 30 PD-related targets to exert synergism, and the same target can be enriched in multiple signal pathways and biological processes, expounding that the decoction can exert synergistic effect on PD by multi-targets and multi-pathways. Furthermore, the molecular docking analysis showed that active compounds and targets can be well combined. These results highlighted the molecular mechanisms underlying the efficiency of SYGCD for PD treatment at a systematic level, investigating thoroughly the innovative therapeutic tactics for PD in traditional Chinese medicine.
帕金森病（PD）是继阿尔茨海默病之后另一种主要的神经退行性疾病，它不仅严重降低了患者的生存率，影响了患者的生活质量，而且给家庭甚至整个社会带来了巨大的负担。迫切需要找到没有副作用的有效药物。本研究采用一种名为网络药理学的创新方法，探索芍药甘草汤（SYGCD）治疗 PD 的活性化合物和治疗靶点。我们共鉴定出 48 种活性化合物，介导 30 个与 PD 相关的靶点，发挥协同作用，并且同一靶点可以富集在多个信号通路和生物学过程中，说明该方剂可以通过多靶点、多途径对 PD 发挥协同作用。此外，分子对接分析表明，活性化合物和靶点可以很好地结合。这些结果从系统水平上强调了 SYGCD 治疗 PD 的分子机制，深入探讨了中医药治疗 PD 的创新治疗策略。
