• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Continued misuse of orphan drug legislation: a life-threatening risk for mexiletine.

作者信息

Postema Pieter G, Schwartz Peter J, Arbelo Elena, Bannenberg Wilbert J, Behr Elijah R, Belhassen Bernard, Brugada Josep, Brugada Pedro, John Camm A, Casado-Arroyo Ruben, 't Hoen Ellen, Hollak Carla E M, Kääb Stefan, Lambiase Pier D, Leenhardt Antoine, Priori Silvia G, Probst Vincent, Stunnenberg Bas C, Tfelt-Hansen Jacob, Van Engelen Baziel G M, Veltmann Christian, Viskin Sami, Wilde Arthur A M

机构信息

Department of Cardiology, Heart Center, Amsterdam University Medical Centers, Academic Medical Center, PO-Box 22700, 1100DE, Amsterdam, The Netherlands, Member of the European Reference Network (ERN) GUARD-Heart.

Instituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin, Milan, Italy. Member of the European Reference Network (ERN) GUARD-Heart.

出版信息

Eur Heart J. 2020 Feb 1;41(5):614-617. doi: 10.1093/eurheartj/ehaa041.

DOI:10.1093/eurheartj/ehaa041
PMID:32006435
Abstract
摘要

相似文献

1
Continued misuse of orphan drug legislation: a life-threatening risk for mexiletine.孤儿药立法的持续滥用：美西律面临的危及生命的风险。
Eur Heart J. 2020 Feb 1;41(5):614-617. doi: 10.1093/eurheartj/ehaa041.
2
Chronic mexiletine therapy for suppression of ventricular arrhythmias.慢性美西律治疗抑制室性心律失常。
Clin Cardiol. 1988 Mar;11(3):132-6. doi: 10.1002/clc.4960110304.
3
Mexiletine: double-blind comparison with procainamide in PVC suppression and open-label sequential comparison with amiodarone in life-threatening ventricular arrhythmias.
Am Heart J. 1985 Nov;110(5):923-31. doi: 10.1016/0002-8703(85)90186-3.
4
Mexiletine in refractory ventricular arrhythmias.
Clin Pharmacol Ther. 1983 Dec;34(6):777-84. doi: 10.1038/clpt.1983.249.
5
Long-term mexiletine for ventricular arrhythmia.长期使用美西律治疗室性心律失常。
Am Heart J. 1984 May;107(5 Pt 2):1091-8. doi: 10.1016/0002-8703(84)90180-7.
6
Intolerance and ineffectiveness of mexiletine in patients with serious ventricular arrhythmias.
Am Heart J. 1986 Aug;112(2):322-6. doi: 10.1016/0002-8703(86)90269-3.
7
Dose independent pharmacokinetics of mexiletine in healthy volunteers.美西律在健康志愿者体内的非剂量依赖性药代动力学。
Br J Clin Pharmacol. 1986 Mar;21(3):319-21. doi: 10.1111/j.1365-2125.1986.tb05196.x.
8
Poisoning due to class 1B antiarrhythmic drugs. Lignocaine, mexiletine and tocainide.1B类抗心律失常药物中毒。利多卡因、美西律和妥卡尼。
Med Toxicol Adverse Drug Exp. 1989 Nov-Dec;4(6):412-28. doi: 10.1007/BF03259923.
9
[The legal regulation of life cycle of orphan pharmaceuticals].[孤儿药生命周期的法律监管]
Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2014 May-Jun(3):37-42.
10
The pharmacokinetics of the enantiomers of mexiletine in humans.美西律对映体在人体中的药代动力学。
Xenobiotica. 1989 Jun;19(6):677-82. doi: 10.3109/00498258909042305.

引用本文的文献

1
Ethanol ablation cost in the United States: An abusive manipulation of drug regulations.美国乙醇消融术的成本：对药品监管的滥用操纵。
Heart Rhythm. 2025 Jan 16. doi: 10.1016/j.hrthm.2024.12.032.
2
Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.长期服用美西律可增加非患病人类诱导多能干细胞衍生心肌细胞中的钠电流。
Biomedicines. 2024 May 29;12(6):1212. doi: 10.3390/biomedicines12061212.
3
Relevance of mexiletine in the era of evolving antiarrhythmic therapy of ventricular arrhythmias.
美西律在不断发展的室性心律失常抗心律失常治疗时代的相关性。
Clin Res Cardiol. 2024 Jun;113(6):791-800. doi: 10.1007/s00392-024-02383-9. Epub 2024 Feb 14.
4
From gene-discovery to gene-tailored clinical management: 25 years of research in channelopathies and cardiomyopathies.从基因发现到基因定制的临床管理：通道病和心肌病研究 25 年。
Europace. 2023 Aug 25;25(8). doi: 10.1093/europace/euad180.
5
Effectiveness and safety of mexiletine in patients at risk for (recurrent) ventricular arrhythmias: a systematic review.美西律治疗（复发性）室性心律失常高危患者的有效性和安全性：系统评价。
Europace. 2022 Nov 22;24(11):1809-1823. doi: 10.1093/europace/euac087.
6
Drug Repurposing for Rare Diseases: A Role for Academia.罕见病的药物再利用：学术界的作用。
Front Pharmacol. 2021 Oct 20;12:746987. doi: 10.3389/fphar.2021.746987. eCollection 2021.