From Endowed Research Department Food for Health, Ochanomizu University, Tokyo, Japan (Y.K., E.S., K.K.).
Department of Cardiology, National Hospital Organization Tokyo Medical Center, Japan (K.S., H.N., Y.M.).
Stroke. 2018 Sep;49(9):2230-2232. doi: 10.1161/STROKEAHA.118.022256.
Background and Purpose- Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to generate carbon monoxide, biliverdin, and iron. Because these products have antiatherogenic properties, HO-1 may play a protective role against atherosclerosis. However, plasma HO-1 levels in patients with carotid atherosclerosis have not been reported. Methods- We investigated plasma HO-1 levels by ELISA in 136 subjects (age, 66±9 years) undergoing carotid ultrasonography. Results- Of the 136 study subjects, carotid plaque was found in 61 subjects (45%). Compared with 75 subjects without plaque, 61 with plaque were older and predominantly male ( P<0.05). Plasma HO-1 levels were higher in subjects with plaque than in those without plaque (median, 0.56 versus 0.44 ng/mL; P<0.05). The percentage of subjects with HO-1 level >0.50 ng/mL was higher in subjects with plaque than without plaque (66% versus 44%; P<0.025). In multivariate analysis, HO-1 level was a significant factor for carotid plaque independent of atherosclerotic risk factors. Odds ratio for plaque was 2.33 (95% CI, 1.15-4.75) for HO-1 level >0.50 ng/mL. Conclusions- Plasma HO-1 levels were high in subjects with carotid plaques, probably reflecting a protective response against carotid atherosclerosis.
背景与目的-血红素加氧酶-1（HO-1）可催化血红素氧化生成一氧化碳、胆红素和铁。由于这些产物具有抗动脉粥样硬化作用，HO-1 可能在对抗动脉粥样硬化中发挥保护作用。然而，颈动脉粥样硬化患者的血浆 HO-1 水平尚未见报道。方法-我们通过 ELISA 法检测了 136 例行颈动脉超声检查者（年龄 66±9 岁）的血浆 HO-1 水平。结果-在 136 例研究对象中，61 例（45%）存在颈动脉斑块。与无斑块的 75 例相比，有斑块者年龄更大且以男性为主（P<0.05）。有斑块者的血浆 HO-1 水平高于无斑块者（中位数：0.56 与 0.44ng/mL；P<0.05）。HO-1 水平>0.50ng/mL 的患者在有斑块者中所占比例高于无斑块者（66%与 44%；P<0.025）。多因素分析显示，HO-1 水平是颈动脉斑块的独立危险因素，HO-1 水平>0.50ng/mL 的斑块比值比为 2.33（95%CI：1.15-4.75）。结论-颈动脉斑块患者的血浆 HO-1 水平较高，可能反映了对颈动脉粥样硬化的一种保护反应。
