School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.
School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.
J Hazard Mater. 2020 May 15;390:122126. doi: 10.1016/j.jhazmat.2020.122126. Epub 2020 Jan 17.
Some new kinds of antibiotics-free antibacterial agents are required to deal with bacterial infections due to the occurrence of drug-resistance. In this work, Cu-based metal-organic framework (HKUST-1) embedded with CuS NPs were fabricated via a simple in-situ sulfuration process. The synthesized MOFs exhibited an highly effective disinfection efficacy of 99.70 % and 99.80 % against Staphylococcus aureus and Escherichia coli within 20 min irradiation of near-infrared (NIR) light, respectively, which was ascribed to the cooperative effects of photodynamic and photothermal effects of the composites. A certain amount of Cu ions of the MOFs were reacted to form CuS NPs, which endowed this composite with outstanding photocatalytic and photothermal performance during NIR light irradiation. Moreover, HKUST-1 that composed of low toxic organic ligand 1,3,5-benzenetricarboxylic acid (HBTC) coordinating copper ions could be a controllable carrier that imposed certain constraint on the NPs. Hence, these CuS@HKUST-1 would be a promising bioplatform for rapid bacteria-killing.
由于耐药性的出现，需要一些新型的抗生素抗菌剂来应对细菌感染。在这项工作中，通过简单的原位硫化法制备了嵌入 CuS NPs 的 Cu 基金属有机骨架（HKUST-1）。合成的 MOFs 在近红外（NIR）光照射 20 min 内对金黄色葡萄球菌和大肠杆菌的杀菌效率分别达到 99.70%和 99.80%，这归因于复合材料的光动力和光热协同效应。一定量的 MOFs 中的 Cu 离子发生反应形成 CuS NPs，这使得该复合材料在 NIR 光照射下具有优异的光催化和光热性能。此外，由低毒有机配体 1,3,5-苯三甲酸（HBTC）配位铜离子组成的 HKUST-1 可以作为 NPs 的可控载体，对其施加一定的约束。因此，这些 CuS@HKUST-1 将是一种很有前途的快速杀菌生物平台。
