Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7, PL 50-368, Wroclaw, Poland; Department of Diagnostic Imaging, 4th Military Hospital, Weigla 5, PL 50-981, Wroclaw, Poland.
Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, PL 50-556, Wroclaw, Poland.
Environ Toxicol Pharmacol. 2020 Apr;75:103332. doi: 10.1016/j.etap.2020.103332. Epub 2020 Jan 24.
The objective of the study was to determine the relationship between serum concentrations of selenium (SeS) and zinc (ZnS), total antioxidant status (TAS) and endothelial function assessed by ultrasonographic method of dilatation of the brachial artery in 141 hypertensive patients. Patients with SeS < median were characterized by a statistically significantly lower flow-mediated dilation (FMD) than patients with SeS ≥ median. Patients with TAS < median were characterized by a significantly lower FMD than patients with TAS ≥ median. Older age, higher BMI, male gender, higher blood total cholesterol, ischemic heart disease, smoking and lower SeS constitute independent predictors of inferior endothelial function, expressed in lower FMD values. Smoking is an independent predictor of lower TAS, and the use of β-blockers and higher serum selenium levels are independent predictors of higher TAS. In summary, a decrease in TAS should be considered as a mechanism of inferior endothelial function in hypertensive patients conditioned by a decrease in SeS.
本研究旨在确定 141 例高血压患者血清硒（SeS）和锌（ZnS）浓度、总抗氧化状态（TAS）与超声肱动脉扩张法评估内皮功能之间的关系。硒浓度低于中位数的患者的血流介导的扩张（FMD）显著低于硒浓度大于或等于中位数的患者。TAS 低于中位数的患者的 FMD 明显低于 TAS 大于或等于中位数的患者。年龄较大、BMI 较高、男性、总胆固醇较高、缺血性心脏病、吸烟和较低的 SeS 是内皮功能较差的独立预测因子，表现为较低的 FMD 值。吸烟是 TAS 降低的独立预测因子，β-受体阻滞剂的使用和较高的血清硒水平是 TAS 升高的独立预测因子。总之，TAS 的降低可能被认为是由 SeS 降低引起的高血压患者内皮功能较差的机制之一。
