College of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan, 250355, China.
Shandong Institute of Traditional Chinese Medicine, Ji'nan, 250014, China.
Biomed Pharmacother. 2020 May;125:109869. doi: 10.1016/j.biopha.2020.109869. Epub 2020 Jan 30.
Ixeris sonchifolia (IS), principally its dried form, is widely used as traditional and folk medicines in some Asian countries, especially China. In this review, we summarized its traditional uses, chemical constituents, quality control measures, pharmacological activities, therapeutic evaluation, toxicity evaluation and clinical applications. 130 chemical constituents isolated from IS have been reported, including flavones, sesquiterpenes, triterpenes, phenylpropanoids, organic acids and others. They showed various pharmacological activities, such as protecting cardiocerebral vascular system, anticancer effect and antiviral etc. The quality control evaluation studies, clinical applications, other possible applications and suggestions for future research also were discussed. The aim of this review is to critically appraise the available literature and suggest directions for further development of IS to improve its medical value and use.
苦苣菜（IS），主要是其干品，在一些亚洲国家，特别是中国，被广泛用作传统和民间药物。在这篇综述中，我们总结了它的传统用途、化学成分、质量控制措施、药理活性、治疗评价、毒性评价和临床应用。从 IS 中分离得到的 130 种化学成分，包括黄酮类、倍半萜类、三萜类、苯丙素类、有机酸等。它们表现出多种药理活性，如保护心脑血管系统、抗癌作用和抗病毒作用等。还讨论了质量控制评价研究、临床应用、其他可能的应用以及对未来研究的建议。本综述的目的是批判性地评价现有文献，并为进一步开发 IS 以提高其药用价值和用途提出方向。
