University of Florida, Gainesville, USA.
Dig Dis Sci. 2020 Mar;65(3):789-796. doi: 10.1007/s10620-020-06104-w.
Necrotizing enterocolitis (NEC) is a poorly defined disease that primarily affects preterm infants. There has not been much progress in the prevention or treatment of NEC since it became recognized as a common problem in preterm infants. Reasons for this lack of progress include the likelihood that different diseases are being put under the same moniker of "NEC," similar to using "diabetes" for the different diseases it represents. In order to make progress, better delineation of the phenotypes that present as NEC will be necessary to clearly establish their pathophysiology, find specific and sensitive biomarkers, and establish preventative regimens. In this review, we summarize some of the entities that are being called NEC, discuss the pathophysiology of the most classic form of NEC, and provide an overview of how we might proceed in the future to make progress in this field.
坏死性小肠结肠炎（NEC）是一种定义不明确的疾病，主要影响早产儿。自 NEC 被认为是早产儿的常见问题以来，在预防或治疗方面并没有太大进展。造成这种进展缓慢的原因包括，不同的疾病可能被归为同一名称的“NEC”，类似于用“糖尿病”来代表它所代表的不同疾病。为了取得进展，有必要更好地区分表现为 NEC 的表型，以明确其病理生理学，找到具体和敏感的生物标志物，并建立预防方案。在这篇综述中，我们总结了一些被称为 NEC 的实体，讨论了最典型形式的 NEC 的病理生理学，并概述了我们未来在这一领域取得进展的方法。
