Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), AP-HP Hôpital Pitié-Salpêtrière, 75013, Paris, France.
Unit of Antibodies in Therapy and Pathology, Institut Pasteur, UMR1222 Inserm, F-75015, Paris, France.
Mucosal Immunol. 2020 Jan;13(1):3-11. doi: 10.1038/s41385-019-0192-y. Epub 2019 Aug 14.
The human intestine is densely colonized with commensal microbes that stimulate the immune system. While secretory Immunoglobulin (Ig) A is known to play a crucial role in gut microbiota compartmentalization, secretory IgM, and systemic IgG have recently been highlighted in host-microbiota interactions as well. In this review, we discuss important aspects of secretory IgA biology, but rather than focusing on mechanistic aspects of IgA impact on microbiota, we stress the current knowledge of systemic antibody responses to whole gut microbiota, in particular their generation, specificities, and function. We also provide a comprehensive picture of secretory IgM biology. Finally, therapeutic and diagnostic implications of these novel findings for the treatment of various diseases are outlined.
人体肠道内定植着大量的共生微生物，这些微生物能够刺激免疫系统。分泌型免疫球蛋白 A（Secretory Immunoglobulin A，简称 IgA）在肠道微生物区系的分隔中起着至关重要的作用，而分泌型免疫球蛋白 M（Secretory Immunoglobulin M，简称 IgM）和系统性 IgG（Systemic IgG）最近也被强调在宿主-微生物相互作用中发挥作用。在这篇综述中，我们讨论了分泌型 IgA 生物学的重要方面，但我们并没有关注 IgA 对微生物影响的机制方面，而是强调了针对整个肠道微生物群的系统性抗体反应的现有知识，特别是它们的产生、特异性和功能。我们还提供了分泌型 IgM 生物学的全面描述。最后，概述了这些新发现对各种疾病的治疗和诊断的治疗和诊断意义。
