双极环加成策略在三组分合成色烯[3',4':3,4]吡啶并[2,1-a]异喹啉衍生物中的应用。
Dipolar cycloaddition strategy for three-component synthesis of chromeno[3',4':3,4]pyrido[2,1-a]isoquinoline derivatives.
机构信息
Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, Fujian, People's Republic of China.
出版信息
Mol Divers. 2021 May;25(2):701-710. doi: 10.1007/s11030-020-10041-1. Epub 2020 Feb 1.
PMID:32008141
Abstract
A rapid and efficient protocol to fused pentacyclic compounds, the chromeno[3',4':3,4]pyrido[2,1-a]isoquinolines, via a diastereoselective 1,4-dipolar cycloaddition reaction of isoquinoline, dialkyl acetylenedicarboxylates, and 3-acetyl coumarins, is described.
摘要
描述了一种通过异喹啉、二烷基乙酰基丙二酸盐和 3-乙酰香豆素的立体选择性 1,4-偶极环加成反应，快速有效地合成稠合五环化合物——色烯[3',4':3,4]吡啶并[2,1-a]异喹啉的方法。
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