Department of Prosthodontics, Faculty of Dental Medicine, Lebanese University, Hadath, Beirut, Lebanon.
Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lebanese University, Hadath, Beirut, Lebanon.
J Mol Neurosci. 2020 May;70(5):790-795. doi: 10.1007/s12031-020-01491-1. Epub 2020 Feb 1.
Cytokines are proteins secreted by diverse types of immune and non-immune cells and play a role in the communication between the immune and nervous systems. Cytokines include lymphokines, monokines, chemokines, interleukins, interferons, colony stimulating factors, and growth factors. They can be both pro- and anti-inflammatory and have autocrine, paracrine, and endocrine activities. These proteins are involved in initiation and persistence of pain, and the progress of hyperalgesia and allodynia, upon stimulating nociceptive sensory neurons, and inducing central sensitization. The objective of this review is to discuss several types of pro- and anti-inflammatory mediators and their relation with inflammatory pain in masticatory muscles.
细胞因子是由多种类型的免疫细胞和非免疫细胞分泌的蛋白质，在免疫和神经系统之间的通讯中发挥作用。细胞因子包括淋巴因子、单核因子、趋化因子、白细胞介素、干扰素、集落刺激因子和生长因子。它们既可以是促炎的，也可以是抗炎的，具有自分泌、旁分泌和内分泌活性。这些蛋白质参与刺激伤害感受感觉神经元和诱导中枢敏化后疼痛的起始和持续，以及痛觉过敏和感觉异常的进展。本综述的目的是讨论几种促炎和抗炎介质及其与咀嚼肌炎性疼痛的关系。
