Chen Z, Li S N, Wang X, Zhang L F, Shao L, Tian Y, Wang Z W
Division of Prevention and Community Health, National Center for Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 102308, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Jan 24;48(1):47-53. doi: 10.3760/cma.j.issn.0253-3758.2020.01.005.
To identify the incidence of hypertension, overweight/obesity in middle-aged population in China, and explore their impact on cardiovascular events. From 2009 to 2010, 12 areas were sampled in China, and about 1 000 subjects aged 35 - 64 from each area were enrolled to collect the basic information, physical examination and blood tests were also performed. From 2016 to 2017, data from 8 835 subjects, who completed the 6 years follow-up, were analyzed.Blood pressure and body mass index(BMI) at both baseline and the follow-up, as well as incidence of hypertension, overweight and obesity, were calculated. Cox proportional hazard model was used to investigate the impacts of hypertension, overweight and obesity on cardiovascular events after adjusting confounders. At the end of follow-up, both BMI and systolic and diastolic blood pressure increased significantly compared with the baseline levels (all 0.001). The cumulative incidence of hypertension, overweight and obesity within 6 years was 39.3%(1 146/2 918), 11.5%(406/3 544) and 4.3%(302/7 025), respectively. Compared with subjects with both normal BMI and blood pressure, people with overweight, obesity, hypertension, overweight with hypertension, and obesity with hypertension faced significantly increased risk of cardiovascular disease ( (95s) were 2.394(1.130-5.073), 3.341(1.454-7.674), 6.047(2.978-12.279), 5.808(2.924-11.539) and 8.716(4.391-17.302), respectively, all 0.05), after adjusting for other confounders. The incidence of overweight, obesity, and hypertension is high in middle-aged people in China. Overweight, obesity and hypertension are associated with significantly increased risk of cardiovascular events during the 6 years follow up.
为确定中国中年人群中高血压、超重/肥胖的发病率，并探讨其对心血管事件的影响。2009年至2010年，在中国抽取了12个地区，每个地区招募了约1000名35 - 64岁的受试者，收集基本信息，同时进行体格检查和血液检测。2016年至2017年，对完成6年随访的8835名受试者的数据进行了分析。计算了基线和随访时的血压和体重指数（BMI），以及高血压、超重和肥胖的发病率。采用Cox比例风险模型在调整混杂因素后研究高血压、超重和肥胖对心血管事件的影响。随访结束时，BMI以及收缩压和舒张压与基线水平相比均显著升高（均P<0.001）。6年内高血压、超重和肥胖的累积发病率分别为39.3%（1146/2918）、11.5%（406/3544）和4.3%（302/7025）。与BMI和血压均正常的受试者相比，超重、肥胖、高血压、超重合并高血压以及肥胖合并高血压的人群在调整其他混杂因素后，心血管疾病风险显著增加（风险比（95%置信区间）分别为2.394（1.130 - 5.073）、3.341（1.454 - 7.674）、6.047（2.978 - 12.279）、5.808（2.924 - 11.539）和8.716（4.391 - 17.302），均P<0.05）。中国中年人群中超重、肥胖和高血压的发病率较高。超重、肥胖和高血压与6年随访期间心血管事件风险的显著增加相关。
