Health Education and Promotion, Research Center for Environmental Determinants of Health (RCEDH), Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Nutrition Sciences, Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran.
BMC Cardiovasc Disord. 2022 Mar 14;22(1):106. doi: 10.1186/s12872-022-02553-5.
Although obesity increases the risk of hypertension, the effect of obesity based on metabolic status on the incidence of hypertension is not known. This study aimed to determine the association between obesity phenotypes including metabolically unhealthy obesity (MUO) and metabolically healthy obesity (MHO) and the risk of hypertension incidence.
We conducted a prospective cohort study on 6747 adults aged 35-65 from Ravansar non-communicable diseases (RaNCD) study. Obesity was defined as body mass index above 30 kg/m and metabolically unhealthy was considered at least two metabolic disorders based on the International Diabetes Federation criteria. Obesity phenotypes were categorized into four groups including MUO, MHO, metabolically unhealthy non obesity (MUNO), and metabolically healthy non obesity (MHNO). Cox proportional hazards regression models were applied to analyze associations with hypertension incidence.
The MHO (HR: 1.37; 95% CI: 1.03-1.86) and MUO phenotypes (HR: 2.44; 95% CI: 1.81-3.29) were associated with higher hypertension risk compared to MHNO. In addition, MUNO phenotype was significantly associated with risk of hypertension incidence (HR: 1.65; 95% CI: 1.29-2.14).
Both metabolically healthy and unhealthy obesity increased the risk of hypertension incidence. However, the increase in metabolically unhealthy phenotype was higher.
肥胖会增加患高血压的风险，但基于代谢状态的肥胖对高血压发病率的影响尚不清楚。本研究旨在确定包括代谢不健康型肥胖（MUO）和代谢健康型肥胖（MHO）在内的肥胖表型与高血压发病率之间的关联。
我们对来自 Ravansar 非传染性疾病（RaNCD）研究的 6747 名年龄在 35-65 岁的成年人进行了一项前瞻性队列研究。肥胖定义为身体质量指数（BMI）超过 30kg/m2，代谢不健康被认为是至少存在两种基于国际糖尿病联合会标准的代谢紊乱。肥胖表型分为 4 组，包括 MUO、MHO、代谢不健康非肥胖（MUNO）和代谢健康非肥胖（MHNO）。应用 Cox 比例风险回归模型分析与高血压发病率的相关性。
与 MHNO 相比，MHO（HR：1.37；95%CI：1.03-1.86）和 MUO 表型（HR：2.44；95%CI：1.81-3.29）与更高的高血压风险相关。此外，MUNO 表型与高血压发病率的风险显著相关（HR：1.65；95%CI：1.29-2.14）。
代谢健康和不健康的肥胖都会增加高血压的发病风险，但代谢不健康表型的增加更为显著。
