女性肺癌：现代流行病。

Lung Cancer in Women: A Modern Epidemic.

机构信息

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Interventional Pulmonary Program, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Chapel Hill, NC 27599-7020, USA.

Division on Pulmonary and Critical Medicine, University of North Carolina at Chapel Hill, 130 Mason Farm Road, Suite 4125, Chapel Hill, NC 27599-7020, USA.

出版信息

Clin Chest Med. 2020 Mar;41(1):53-65. doi: 10.1016/j.ccm.2019.10.005. Epub 2020 Jan 2.

DOI:10.1016/j.ccm.2019.10.005

PMID:32008629

Abstract

Lung cancer in women is a modern epidemic and a major health crisis. Cigarette smoking remains the most important risk factor for lung cancer, and unfortunately smoking rates are either stabilized or continue to increase among women. Women may not be more susceptible to the carcinogenic effects of tobacco, but the biology of lung cancer differs between the sexes. This paper summarizes the biological sex differences in lung cancer, including molecular abnormalities, growth factor receptors, hormonal influences, DNA repair capacity, as well as differences in the histology and treatment outcomes of lung cancer in women.

摘要

女性肺癌是一种现代流行病，也是一个主要的健康危机。吸烟仍然是肺癌最重要的危险因素，不幸的是，女性的吸烟率要么稳定，要么继续上升。女性可能对烟草的致癌作用不那么敏感，但肺癌的生物学在性别之间存在差异。本文总结了肺癌的生物学性别差异，包括分子异常、生长因子受体、激素影响、DNA 修复能力，以及女性肺癌的组织学和治疗结果的差异。