Department of Laboratory Medicine and Pathobiology, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.
Department of Obstetrics, Gynecology, and RS, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA 15213, USA; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Magee-Womens Research Institute, 204 Craft Avenue, Suite A208, Pittsburgh, PA 15213, USA.
Obstet Gynecol Clin North Am. 2020 Mar;47(1):17-28. doi: 10.1016/j.ogc.2019.10.001. Epub 2019 Dec 18.
Cardiovascular disease remains the leading killer of women, with sex-specific manifestation, mechanisms, and morbidity. Preeclampsia, fetal growth restriction, and a subset of preterm births demonstrate aberrancies in the maternal vessels supplying the placenta and damage to the placental parenchyma consistent with hypoxic/ischemic or oxidative injury. This constellation of findings, maternal vascular malperfusion (MVM) lesions, may hold the key to understanding and identifying the elevated risk for early cardiovascular disease in women who experience adverse pregnancy outcomes. This intriguing possibility has only begun to be examined, but accumulating evidence is compelling and is reviewed here.
心血管疾病仍然是女性的主要杀手，具有性别特异性的表现、机制和发病率。子痫前期、胎儿生长受限和一部分早产显示母体供应胎盘的血管异常以及胎盘实质损伤，符合缺氧/缺血或氧化损伤。这一系列发现，即母体血管功能不良（MVM）病变，可能是理解和识别经历不良妊娠结局的女性早期心血管疾病风险升高的关键。这种有趣的可能性才刚刚开始被研究，但越来越多的证据令人信服，本文对此进行了综述。
