Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Psychiatry, Texas Children's Hospital, Houston, TX, USA.
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Psychiatry, Texas Children's Hospital, Houston, TX, USA.
Psychiatr Clin North Am. 2020 Mar;43(1):95-111. doi: 10.1016/j.psc.2019.10.009. Epub 2019 Nov 30.
Pediatric bipolar disorder (PBD) is a severe and chronic illness. The occurrence of mixed symptoms might add further risk of recurrence of treatment resistance and suicidality. Early recognition and treatment of mixed symptoms might prevent illness progression and development of suicide attempts. This article provides an update on the epidemiology, clinical profile, and treatment of youth with PBD with mixed states. Mixed states in PBD are characterized by higher rates of suicide and more chronic symptoms, and are associated with younger age of onset and greater comorbidity. A careful assessment for mixed states using standardized criteria is essential.
儿童双相障碍（PBD）是一种严重且慢性的疾病。混合症状的出现可能会进一步增加治疗抵抗和自杀的风险。早期识别和治疗混合症状可能有助于防止疾病进展和自杀企图的发生。本文就儿童 PBD 混合状态的流行病学、临床特征和治疗进行了更新。PBD 中的混合状态以更高的自杀率和更慢性症状为特征，与发病年龄较小和共病较多有关。使用标准化标准对混合状态进行仔细评估至关重要。
