Perinatal Center for Maternity and Neonates, Yokohama City University Medical Center.
Department of Biostatistics, Yokohama City University Graduate School of Medicine.
Jpn J Infect Dis. 2020 May 22;73(3):210-213. doi: 10.7883/yoken.JJID.2019.116. Epub 2020 Jan 31.
The aim of this study was to clarify the risk factors for chlamydial infection and determine whether infection during pregnancy is associated with preterm birth in Japanese women. The subjects were women who underwent Chlamydia trachomatis polymerase chain reaction testing during a singleton pregnancy and delivered after the 22nd week of gestation at a tertiary care center between January 1, 2000 and December 31, 2016. We compared Chlamydia-positive (n = 259) and Chlamydianegative (n = 1,974) groups and evaluated the pregnancy outcomes. The Chlamydia-positive group had a higher rate of public assistance coverage, smoking during pregnancy, nulliparity, lack of a partner, presence of other sexually transmitted infections, high-risk social status, and younger age (P < 0.01). The incidence of preterm births was not different between the groups, with an odds ratio of 0.95 (95% confidence interval: 0.62-1.46). The incidences of low birth weight deliveries, premature rupture of membranes, and preterm premature rupture of membranes prior to the 37th week were also comparable between the groups. Chlamydial infection during pregnancy had no effect on preterm birth, even after adjustment for confounding factors.
本研究旨在阐明沙眼衣原体感染的危险因素，并确定妊娠期感染是否与日本女性早产有关。研究对象为 2000 年 1 月 1 日至 2016 年 12 月 31 日期间在一家三级保健中心接受单胎妊娠沙眼衣原体聚合酶链反应检测并在妊娠 22 周后分娩的女性。我们比较了沙眼衣原体阳性（n = 259）和沙眼衣原体阴性（n = 1974）组，并评估了妊娠结局。沙眼衣原体阳性组的公共援助覆盖率、妊娠期间吸烟、未婚、无伴侣、存在其他性传播感染、高危社会地位和年龄较小的比例较高（P < 0.01）。两组的早产发生率无差异，优势比为 0.95（95%置信区间：0.62-1.46）。两组低出生体重儿、胎膜早破和 37 周前早产胎膜早破的发生率也相似。即使在校正混杂因素后，妊娠期沙眼衣原体感染对早产也没有影响。
