The Generation R Study group, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Eur J Epidemiol. 2011 Jun;26(6):493-502. doi: 10.1007/s10654-011-9586-1. Epub 2011 May 3.
Chlamydia trachomatis infection is the most prevalent bacterial sexually transmitted infection and may influence pregnancy outcome. This study was conducted to assess the effect of chlamydial infection during pregnancy on premature delivery and birthweight. Pregnant women attending a participating midwifery practice or antenatal clinic between February 2003 and January 2005 were eligible for the study. From 4,055 women self-administered questionnaires and urine samples, tested by PCR, were analysed for C. trachomatis infection. Pregnancy outcomes were obtained from midwives and hospital registries. Gestational ages and birthweights were analysed for 3,913 newborns. The C. trachomatis prevalence was 3.9%, but varied by age and socio-economic background. Chlamydial infection was, after adjustment for potential confounders, associated with preterm delivery before 32 weeks (OR 4.35 [95% CI 1.3, 15.2]) and 35 weeks gestation (OR 2.66 [95% CI 1.1, 6.5]), but not with low birthweight. Of all deliveries before 32 weeks and 35 weeks gestation 14.9% [95% CI 4.5, 39.5] and 7.4% [95% CI 2.5, 20.1] was attributable to C. trachomatis infection. Chlamydia trachomatis infection contributes significantly to early premature delivery and should be considered a public health problem, especially in young women and others at increased risk of C. trachomatis infection.
沙眼衣原体感染是最常见的细菌性性传播感染，可能会影响妊娠结局。本研究旨在评估妊娠期沙眼衣原体感染对早产和低出生体重的影响。2003 年 2 月至 2005 年 1 月期间，参加参与助产士执业或产前诊所的孕妇有资格参加这项研究。从 4055 名女性中自行填写问卷，并通过 PCR 检测尿液样本，分析沙眼衣原体感染情况。妊娠结局从助产士和医院登记处获得。对 3913 名新生儿的胎龄和出生体重进行了分析。沙眼衣原体的患病率为 3.9%，但因年龄和社会经济背景而异。在调整了潜在混杂因素后，沙眼衣原体感染与 32 周前（OR 4.35 [95%CI 1.3, 15.2]）和 35 周妊娠（OR 2.66 [95%CI 1.1, 6.5]）的早产相关，但与低出生体重无关。所有 32 周前和 35 周前的分娩中，14.9% [95%CI 4.5, 39.5]和 7.4% [95%CI 2.5, 20.1]归因于沙眼衣原体感染。沙眼衣原体感染对早期早产有显著影响，应被视为公共卫生问题，尤其是在年轻女性和其他感染沙眼衣原体风险增加的人群中。
