Woodworth C H, Johnson A K
Department of Psychology, University of Iowa, Iowa City 52242.
Physiol Behav. 1988;43(5):609-16. doi: 10.1016/0031-9384(88)90215-6.
The effect of social isolation, consisting of individual housing in the vivarium under standard conditions and imposed on male rats older than 90 days, was assessed on tactile startle reactivity, nociception, resting heart rate and arterial blood pressure, and on intercorrelations among these variables. Tactile startle was affected by stimulus intensity, repeated trials and time of testing relative to the light/dark cycle, but not by social isolation from 1 to 29 days. Hot-plate latency was not affected by individual housing from 12 to 43 days. Blood pressure and heart rate were negatively correlated with isolation from 9 to 58 days, showing a significant decline over increasing days of isolation. Although not affected directly by isolation, tactile startle was affected secondarily by differences in blood pressure produced by individual housing. Rats with lower resting pressures responded to low-intensity startle stimuli that were not effective in rats with higher pressures, indicating a threshold difference and suggesting the hypothesis that blood pressure acts to modulate sensory reactivity.
对90日龄以上雄性大鼠施加标准条件下饲养于动物饲养室的个体隔离方式，以此评估社会隔离对触觉惊跳反应、痛觉感受、静息心率和动脉血压的影响，以及这些变量之间的相互关系。触觉惊跳受刺激强度、重复试验以及相对于明暗周期的测试时间影响，但在1至29天的社会隔离期间不受影响。热板潜伏期在12至43天的个体饲养期间不受影响。血压和心率在9至58天的隔离期间与隔离呈负相关，随着隔离天数增加呈现显著下降。触觉惊跳虽未直接受隔离影响，但个体饲养产生的血压差异对其产生了间接影响。静息血压较低的大鼠对低强度惊跳刺激有反应，而这种刺激对血压较高的大鼠无效，这表明存在阈值差异，并提出了血压调节感觉反应性的假说。
