Schaeffer M C
Physiol Behav. 1987;40(4):473-8. doi: 10.1016/0031-9384(87)90032-1.
Vitamin B-6 deficient rats exhibit changes in behavior, sensory function, and other nervous system abnormalities such as convulsive seizures and motor disturbances. Sensorimotor reactivity was evaluated quantitatively by measuring auditory and tactile startle responses in 12 week old female Long-Evans rats fed a diet devoid of added vitamin B-6 (DEF) or a control diet, either ad lib (AL-CON) or pair-fed to deficient rats (PF-CON). Deficiency was confirmed with a tryptophan-load test administered to a separate group of rats fed simultaneously according to the same protocol. At week 18, body weight and feed efficiency were different among groups (p less than 0.001), and were lowest in DEF. Amplitude of response to both acoustic and tactile stimuli was depressed in DEF compared to both control groups, which generally did not differ in response. This effect was seen most dramatically in responses to the acoustic stimulus (p = 0.034), and especially to the first presentation (p = 0.017). Latency to maximum response was not affected by diet. Possible mechanisms for this nervous system abnormality, not previously reported in vitamin B-6 deficiency, are discussed.
维生素B-6缺乏的大鼠会出现行为、感觉功能变化以及其他神经系统异常，如惊厥发作和运动障碍。通过测量12周龄雌性Long-Evans大鼠的听觉和触觉惊吓反应，对感觉运动反应性进行定量评估，这些大鼠分别喂食不含添加维生素B-6的饮食（DEF）或对照饮食，自由采食（AL-CON）或与缺乏维生素B-6的大鼠配对喂食（PF-CON）。对另一组按照相同方案同时喂食的大鼠进行色氨酸负荷试验，以确认维生素B-6缺乏情况。在第18周时，各组之间的体重和饲料效率存在差异（p小于0.001），且在DEF组中最低。与两个对照组相比，DEF组对听觉和触觉刺激的反应幅度均降低，而两个对照组的反应通常没有差异。这种效应在对听觉刺激的反应中最为明显（p = 0.034），尤其是对首次呈现的刺激（p = 0.017）。达到最大反应的潜伏期不受饮食影响。本文讨论了这种先前在维生素B-6缺乏中未报道的神经系统异常的可能机制。
