Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering , Tongji University , Shanghai 201804 , People's Republic of China.
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9118-9131. doi: 10.1021/acsami.9b23536. Epub 2020 Feb 13.
Injectable and self-healing hydrogels with thermoresponsiveness as smart hydrogels displayed injectability, automatic healing, and phase and volume changes as well. Here, the thermoresponsive self-healing hydrogel was prepared via the formation of dynamic covalent enamine bonds between the amino groups in polyetherimide (PEI) and the acetoacetate groups in the four-armed star-shaped poly(2-(dimethylamino)ethyl methacrylate--2-hydroxyethyl methacrylate) modified with -butyl acetoacetate (-BAA), SP(DMAEMA--HEMA-AA). After adding polydopamine nanoparticles (PDA NPs), the SP(DMAEMA--HEMA-AA)/PEI/PDA-NP nanocomposite hydrogel presented phase change and volume shrinkage under near-infrared (NIR) irradiation. The thermoresponsive nanocomposite hydrogel loaded with the anticancer drug doxorubicin (DOX) could be injected into the 4T1 tumor by intratumoral injection. After NIR laser irradiation, the temperature of the hydrogel increased because of the photothermal effect of PDA NPs inducing local hyperthermia. Because the hydrophilicity-hydrophobicity transition of the hydrogel occurred, DOX molecules were squeezed out from the hydrogel at temperatures higher than its lower critical solution temperature (LCST) and the tumor cells suffered from internal stress from the shrunk hydrogel. The injectable nanocomposite hydrogel not only demonstrated the synergism of highly efficient thermochemotherapy but also showed the function of improving drug utilization and precise treatment to reduce the side effects of drugs.
具有温敏性的可注射自修复水凝胶作为智能水凝胶表现出可注射性、自动修复性以及相态和体积变化等特性。在这里，通过在聚醚酰亚胺（PEI）中的氨基与经丁酸修饰的四臂星形聚（2-（二甲氨基）乙基甲基丙烯酸酯-2-羟乙基甲基丙烯酸酯）（-BAA）中的乙酰乙酸基团之间形成动态共价烯胺键，制备了温敏自修复水凝胶 SP(DMAEMA--HEMA-AA)。加入聚多巴胺纳米粒子（PDA NPs）后，SP(DMAEMA--HEMA-AA)/PEI/PDA-NP 纳米复合水凝胶在近红外（NIR）照射下发生相转变和体积收缩。负载阿霉素（DOX）的温敏纳米复合水凝胶可以通过瘤内注射注入 4T1 肿瘤。近红外激光照射后，由于 PDA NPs 的光热效应导致局部过热，水凝胶的温度升高。由于水凝胶的亲水性-疏水性转变，DOX 分子在高于其低临界溶液温度（LCST）的温度下从水凝胶中挤出，肿瘤细胞因收缩的水凝胶而遭受内部压力。可注射纳米复合水凝胶不仅表现出高效热化疗的协同作用，还显示出提高药物利用率和精确治疗的功能，以减少药物的副作用。
