采用 HPLC-MS 和 HRMS 快速鉴定和结构表征 中的聚氧孕甾烷糖苷。
Rapid identification and structural characterization of polyoxypregnane glycosides in by HPLC-MS and HRMS.
机构信息
Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
出版信息
J Asian Nat Prod Res. 2021 Jan;23(1):9-19. doi: 10.1080/10286020.2020.1715951. Epub 2020 Feb 3.
By HPLC-MS and HRMS analyses, the structures of 52 polyoxypregnane glycosides were rapidly inferred from Hemsl on the basis of their sodium-cationized molecules [M + Na] and predominant diagnostic ions resulting from the saccharic chain on C3 and the neutral loss of substituent on C11 and C12. Compounds and significantly inhibited LPS-stimulated splenocyte proliferation .[Formula: see text].
通过 HPLC-MS 和 HRMS 分析，Hemsl 基于糖链在 C3 上产生的加钠离子分子 [M + Na] 和主要诊断离子以及 C11 和 C12 上取代基的中性丢失，快速推断出 52 种聚氧孕甾烷糖苷的结构。化合物 和 显著抑制 LPS 刺激的脾细胞增殖。[公式：见正文]。
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