六种来自中华南山藤（Dregea sinensis Hemsl.）的新型C-21甾体苷类化合物
Six new C-21 steroidal glycosides from Dregea sinensis Hemsl.
作者信息
Liu Xiu-Jie, Shi Yu, Jia Shao-Hua, Deng Yu-Lin, Lv Fang, Dai Rong-Ji
机构信息
a School of Life Science , Beijing Institute of Technology , Beijing 100081 , China.
b School of Basic Medical Sciences , Shanxi Medical University , Taiyuan 030001 , China.
出版信息
J Asian Nat Prod Res. 2017 Aug;19(8):745-753. doi: 10.1080/10286020.2017.1281912. Epub 2017 Feb 13.
Six new C-21 steroidal glycosides (1-6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC 19.54 ± 0.91 μM), and compounds 1-4 had significant effects against IL-2R and TNFR2 (IC 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).
从中华萝摩的根部分离出6种新的C-21甾体糖苷（1-6），并通过广泛的核磁共振、质谱和红外光谱分析对其结构进行了阐明。对分离得到的化合物进行了抗肿瘤活性评估，结果表明化合物3在Jurkat细胞中具有中等活性（IC50为19.54±0.91μM），化合物1-4对IL-2R和TNFR2有显著作用（IC50为1.518±0.06μM至5.9±0.07μM）。
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