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老年人群股骨颈骨折术后血清白蛋白水平预测术后肺炎的发生。

Preoperative Serum Albumin Level As A Predictor Of Postoperative Pneumonia After Femoral Neck Fracture Surgery In A Geriatric Population.

机构信息

Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, People's Republic of China.

Department of Respiratory and Gastroenterology, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710054, People's Republic of China.

出版信息

Clin Interv Aging. 2019 Nov 13;14:2007-2016. doi: 10.2147/CIA.S231736. eCollection 2019.

Abstract

PURPOSE

Femoral neck fracture usually occurs in the geriatric population. Postoperative pneumonia (POP) is known to be devastated, and it is the most frequent complication among patients receiving surgical treatment for femoral neck fractures. However, whether patients who have hypoalbuminaemia are susceptible to the development of POP is a serious concern, although it has not been investigated. We attempted to investigate the association between newly developed POP and hypoalbuminaemia and to identify whether hypoalbuminaemia is an independent risk factor for POP after femoral neck fracture in geriatric population.

PATIENTS AND METHODS

We retrospectively reviewed the records from the first 30 days after surgery of patients who were ≥65 years of age and who had a femoral neck fracture treated with surgery between January 2018 and December 2018 at the Honghui Hospital, Xi'an Jiaotong University. Patients were divided into two groups based on whether they did or did not experience POP, and their clinical characteristics were compared. Binomial logistic regression was used to identify potential risk factors of POP by analysing demographic factors, preoperative comorbidities, laboratory results, and surgical factors.

RESULTS

A total of 720 patients were included in the analysis, and 54 patients experienced POP. The incidence of POP after surgical treatment for a femoral neck fracture in this geriatric population was 7.5%. In addition, patients with POP had significantly longer hospital stays than patients without POP. The binary logistic regression analysis revealed that preoperative hypoalbuminaemia [odds ratio =5.187, 95% confidence interval (CI): 2.561-10.506, P<0.0001], COPD (OR =3.819, 95% CI: 1.247-11.701, P=0.019), prior stroke (OR =3.107, 95% CI: 1.470-6.568, P=0.003) and the time from injury to surgery (OR =1.076, 95% CI: 1.034-1.119, P<0.0001) were predominant and independent risk factors associated with POP after femoral neck fracture in this geriatric population.

CONCLUSION

The current study revealed that among a geriatric population admitted for femoral neck fracture surgery, preoperative hypoalbuminaemia was a predictor of POP, followed by COPD, prior stroke and the time from injury to surgery. Thus, patients who undergo femoral neck fracture surgery and have preoperative hypoalbuminaemia should receive additional monitoring and perioperative care.

摘要

目的

股骨颈骨折通常发生在老年人群中。术后肺炎(POP)是毁灭性的,它是股骨颈骨折接受手术治疗的患者中最常见的并发症。然而,患有低蛋白血症的患者是否容易发生 POP 是一个严重的问题,尽管尚未对此进行调查。我们试图探讨新发生的 POP 与低蛋白血症之间的关系,并确定低蛋白血症是否是老年人群股骨颈骨折后发生 POP 的独立危险因素。

患者和方法

我们回顾性分析了 2018 年 1 月至 2018 年 12 月期间在西安交通大学附属红会医院接受手术治疗的年龄≥65 岁的股骨颈骨折患者术后 30 天内的病历。根据是否发生 POP,将患者分为两组,并比较其临床特征。使用二项逻辑回归分析通过分析人口统计学因素、术前合并症、实验室结果和手术因素来确定 POP 的潜在危险因素。

结果

共纳入 720 例患者,54 例患者发生 POP。在这个老年人群中,手术后股骨颈骨折发生 POP 的发生率为 7.5%。此外,发生 POP 的患者的住院时间明显长于未发生 POP 的患者。二元逻辑回归分析显示,术前低蛋白血症[比值比(OR)=5.187,95%置信区间(CI):2.561-10.506,P<0.0001]、慢性阻塞性肺疾病(OR=3.819,95%CI:1.247-11.701,P=0.019)、既往脑卒中(OR=3.107,95%CI:1.470-6.568,P=0.003)和从受伤到手术的时间(OR=1.076,95%CI:1.034-1.119,P<0.0001)是与该老年人群中股骨颈骨折后发生 POP 的主要且独立的危险因素。

结论

本研究表明,在接受股骨颈骨折手术的老年人群中,术前低蛋白血症是 POP 的预测因素,其次是 COPD、既往脑卒中以及从受伤到手术的时间。因此,接受股骨颈骨折手术且术前低蛋白血症的患者应接受额外的监测和围手术期护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc9/6859085/75356e57851d/CIA-14-2007-g0001.jpg

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