Goossens Maria E, Van den Bulcke Marc, Gevaert Thierry, Meheus Lydie, Verellen Dirk, Cosset Jean-Marc, Storme Guy
Cancer Centre, Sciensano (Scientific Institute of Public Health), 1050 Brussels, Belgium.
Department of Radiotherapy, University Hospital Brussels, Vrije Universiteit Brussel, 1050 Brussel, Belgium.
Ecancermedicalscience. 2019 Dec 9;13:982. doi: 10.3332/ecancer.2019.982. eCollection 2019.
Particle, essentially, proton radiotherapy (RT) could provide some benefits over photon RT, especially in reducing the side effects of RT. We performed a systematic review to identify the performed randomised clinical trials (RCTs) and ongoing RCTs comparing particle RT with photon therapy. So far, there are no results available from phase 3 RCTs comparing particle RT with photon therapy. Furthermore, the results on side effects comparing proton and carbon ion beam RT with photon RT do vary. The introduction of new techniques in photon RT, such as image-guided RT (IGRT), intensity-modulated RT (IMRT), volumetric arc therapy (VMAT) and stereotactic body RT (SBRT) was already effective in reducing side effects. At present, the lack of evidence limits the indications for proton and carbon ion beam RTs and makes the particle RT still experimental.
从本质上讲，粒子放疗（RT）相较于光子放疗可能具有一些优势，尤其是在减少放疗副作用方面。我们进行了一项系统综述，以确定已开展的比较粒子放疗与光子放疗的随机临床试验（RCT）以及正在进行的此类试验。到目前为止，尚无3期RCT比较粒子放疗与光子放疗的结果。此外，比较质子和碳离子束放疗与光子放疗的副作用结果确实存在差异。光子放疗中新技术的引入，如图像引导放疗（IGRT）、调强放疗（IMRT）、容积弧形调强放疗（VMAT）和立体定向体部放疗（SBRT），在减少副作用方面已经很有效。目前，证据的缺乏限制了质子和碳离子束放疗的适应症，使得粒子放疗仍处于试验阶段。
