Upadhyaya Vandan D, Shariff Mohammed Z, Mathew Roy O, Hossain Mohammad A, Asif Arif, Vachharajani Tushar J
Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.
Division of Nephrology, Department of Medicine, Columbia VA Health Care Center, 6439 Garners Ferry Rd, Columbia, SC 29209, USA.
J Clin Med Res. 2020 Jan;12(1):1-5. doi: 10.14740/jocmr3938. Epub 2020 Jan 6.
Acute respiratory distress syndrome (ARDS) is a major cause of mortality in adults with acute hypoxic respiratory failure and can predispose those afflicted to develop acute kidney injury (AKI). In the setting where AKI and ARDS overlap, incidence of mortality, length of intensive care unit stay, and complexity of management increases drastically. Lung protective ventilation strategy and conservative fluid management are the main focus of therapy in patients with ARDS, but have major implications on renal function. This review aims to provide concise discussion of pathophysiology, ventilation, and fluid management strategies as it relates to AKI in the setting of ARDS.
急性呼吸窘迫综合征（ARDS）是成人急性低氧性呼吸衰竭的主要死亡原因，并且会使患者易患急性肾损伤（AKI）。在AKI和ARDS重叠的情况下，死亡率、重症监护病房住院时间以及管理复杂性会大幅增加。肺保护性通气策略和保守的液体管理是ARDS患者治疗的主要重点，但对肾功能有重大影响。本综述旨在简要讨论与ARDS背景下AKI相关的病理生理学、通气和液体管理策略。
