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本文引用的文献

1
Time-Resolved Ultra-High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy.用于选择性视网膜治疗实时监测的时间分辨超高分辨率光学相干断层扫描术
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6654-62. doi: 10.1167/iovs.15-17151.
2
Tissue response of selective retina therapy by means of a feedback-controlled energy ramping mode.通过反馈控制能量斜坡模式进行选择性视网膜治疗的组织反应。
Clin Exp Ophthalmol. 2014 Dec;42(9):846-55. doi: 10.1111/ceo.12342. Epub 2014 May 13.
3
Nanosecond pulse lasers for retinal applications.用于视网膜应用的纳秒脉冲激光器。
Lasers Surg Med. 2011 Aug;43(6):499-510. doi: 10.1002/lsm.21087.
4
Improving the therapeutic window of retinal photocoagulation by spatial and temporal modulation of the laser beam.通过对激光光束的时空调制来提高视网膜光凝的治疗窗。
J Biomed Opt. 2011 Feb;16(2):028004. doi: 10.1117/1.3542045.
5
Role of tissue optics and pulse duration on tissue effects during high-power laser irradiation.组织光学和脉冲持续时间在高功率激光照射期间对组织效应的作用。
Appl Opt. 1993 May 1;32(13):2447-54. doi: 10.1364/AO.32.002447.
6
Elevation of plasma membrane permeability upon laser irradiation of extracellular microbubbles.激光辐照细胞外微泡会提高细胞膜通透性。
Lasers Med Sci. 2010 Jul;25(4):587-94. doi: 10.1007/s10103-010-0773-1. Epub 2010 Mar 20.
7
Comparison of threshold irradiances and online dosimetry for selective retina treatment (SRT) in patients treated with 200 nanoseconds and 1.7 microseconds laser pulses.接受200纳秒和1.7微秒激光脉冲治疗的患者中，选择性视网膜治疗（SRT）的阈值辐照度与在线剂量测定的比较。
Lasers Surg Med. 2008 Nov;40(9):616-24. doi: 10.1002/lsm.20685.
8
Femtosecond-laser-induced nanocavitation in water: implications for optical breakdown threshold and cell surgery.飞秒激光诱导水中的纳米空化：对光学击穿阈值和细胞手术的影响。
Phys Rev Lett. 2008 Jan 25;100(3):038102. doi: 10.1103/PhysRevLett.100.038102. Epub 2008 Jan 23.
9
Investigation of selective retina treatment (SRT) by means of 8 ns laser pulses in a rabbit model.在兔模型中利用8纳秒激光脉冲对选择性视网膜治疗（SRT）进行研究。
Lasers Surg Med. 2008 Jan;40(1):20-7. doi: 10.1002/lsm.20592.
10
Optical detection of intracellular cavitation during selective laser targeting of the retinal pigment epithelium: dependence of cell death mechanism on pulse duration.视网膜色素上皮细胞选择性激光靶向过程中细胞内空化的光学检测：细胞死亡机制对脉冲持续时间的依赖性。
J Biomed Opt. 2007 Nov-Dec;12(6):064034. doi: 10.1117/1.2804078.

亚微秒激光脉冲整形在选择性视网膜治疗中控制微空化的潜力。

Potential of sub-microsecond laser pulse shaping for controlling microcavitation in selective retinal therapies.

作者信息

Deladurantaye Pascal, Méthot Sébastien, Mermut Ozzy, Galarneau Pierre, Rochette Patrick J

机构信息

Axe Médecine Régénératrice, Centre de recherche du CHU de Québec- Université Laval, Hôpital du Saint-Sacrement, Québec, Canada.

Centre de recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Université Laval, Québec, Canada.

出版信息

Biomed Opt Express. 2019 Dec 6;11(1):109-132. doi: 10.1364/BOE.11.000109. eCollection 2020 Jan 1.

DOI:10.1364/BOE.11.000109
PMID:32010504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6968749/
Abstract

Pilot results showing the potential of sub-microsecond laser pulse shaping to optimize thermomechanical confinement in laser-tissue interactions involving microcavitation are presented. Model samples based on aqueous suspensions of retinal melanosomes and eumelanin particles were irradiated at 532 nm with nanosecond laser pulses and picosecond laser pulse trains having differing shapes and durations. The cavitation threshold radiant exposure and the bubble lifetime above the threshold were measured using a pump-probe setup and sub-nanosecond time-resolved imaging. Both quantities were found to strongly depend on the pulse format. These results suggest that sub-microsecond laser pulse shaping could be exploited to optimize precision and control in numerous applications of laser-directed microcavitation, including selective retinal laser treatments.

摘要

本文展示了初步结果，表明亚微秒激光脉冲整形在涉及微空化的激光与组织相互作用中优化热机械限制方面具有潜力。基于视网膜黑素体和真黑素颗粒水悬浮液的模型样本，用具有不同形状和持续时间的纳秒激光脉冲和皮秒激光脉冲序列在532nm波长下进行照射。使用泵浦-探测装置和亚纳秒时间分辨成像测量空化阈值辐射曝光和高于阈值的气泡寿命。发现这两个量都强烈依赖于脉冲形式。这些结果表明，亚微秒激光脉冲整形可用于优化激光定向微空化的众多应用中的精度和控制，包括选择性视网膜激光治疗。