一项针对轻度便秘健康成年人的含亚种FC补充剂的剂量探索研究。
A dose-finding study for a supplement containing subsp. FC in healthy adults with mild constipation.
作者信息
Gotoh Yayoi, Nanba Fumio, Shioya Nobuhiko, Sugimura Haruhi, Suzuki Toshio
机构信息
Fujicco Co., Ltd., 6-13-4 Minatojima-nakamachi, Chuo-ku, Kobe, Hyogo 650-8558, Japan.
KSO Corporation, 1-9-7-7F Shibaura, Minato-ku, Tokyo 105-0023, Japan.
出版信息
Biosci Microbiota Food Health. 2020;39(1):19-22. doi: 10.12938/bmfh.19-009. Epub 2019 Sep 10.
A dose-escalation study was conducted to find the effective dose of subsp. FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of FC (dose level 1, 1 × 10 cfu; dose level 2, 2 × 10 cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 10 cfu FC improves defecation.
进行了一项剂量递增研究，以确定亚种FC改善健康受试者排便的有效剂量。招募了27名受试者，连续两周每天服用安慰剂以及两个剂量水平的FC（剂量水平1，1×10cfu；剂量水平2，2×10cfu）胶囊。剂量水平2使排便频率（次/周）显著增加，剂量水平1使粪便量（单位/周）显著增加。这项剂量递增研究表明，摄入至少1×10cfu的FC可改善排便。
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