• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Editorial: Isocyanide-Based Multicomponent Reactions.

作者信息

Rudick Jonathan G, Shaabani Shabnam, Dömling Alexander

机构信息

Department of Chemistry, Stony Brook University, Stony Brook, NY, United States.

Department of Drug Design, University of Groningen, Groningen, Netherlands.

出版信息

Front Chem. 2020 Jan 15;7:918. doi: 10.3389/fchem.2019.00918. eCollection 2019.

DOI:10.3389/fchem.2019.00918
PMID:32010668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6974536/
Abstract
摘要

相似文献

1
Editorial: Isocyanide-Based Multicomponent Reactions.社论：基于异腈的多组分反应
Front Chem. 2020 Jan 15;7:918. doi: 10.3389/fchem.2019.00918. eCollection 2019.
2
Synthesis of imidazo[1,2-]pyridine-containing peptidomimetics by tandem of Groebke-Blackburn-Bienaymé and Ugi reactions.通过格罗布克-布莱克本-比纳梅反应和乌吉反应串联合成含咪唑并[1,2 - ]吡啶的拟肽
Beilstein J Org Chem. 2023 May 26;19:727-735. doi: 10.3762/bjoc.19.53. eCollection 2023.
3
Groebke-Blackburn-Bienaymé multicomponent reaction: emerging chemistry for drug discovery.格罗布克-布莱克本-比内梅多组分反应：药物发现的新兴化学
Mol Divers. 2016 Feb;20(1):233-54. doi: 10.1007/s11030-015-9602-6. Epub 2015 May 28.
4
Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application.固相上的异氰化物多组分反应：最新进展及未来应用。
Int J Mol Sci. 2020 Dec 1;21(23):9160. doi: 10.3390/ijms21239160.
5
New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized.知名氨基唑在异腈基多组分反应中的新技巧以及所合成化合物的抗菌活性
Beilstein J Org Chem. 2017 May 31;13:1050-1063. doi: 10.3762/bjoc.13.104. eCollection 2017.
6
Isocyanide Multicomponent Reactions on Solid-Phase-Coupled DNA Oligonucleotides for Encoded Library Synthesis.固相偶联 DNA 寡核苷酸的异氰化物多组分反应用于编码文库合成。
Org Lett. 2019 Sep 20;21(18):7238-7243. doi: 10.1021/acs.orglett.9b02448. Epub 2019 Aug 29.
7
Diversity-Oriented Synthesis of [2.2]Paracyclophane-derived Fused Imidazo[1,2-a]heterocycles by Groebke-Blackburn-Bienaymé Reaction: Accessing Cyclophanyl Imidazole Ligands Library.导向多样性的[2.2]并环芳烷衍生稠合咪唑并[1,2-a]杂环的 Groebke-Blackburn-Bienaymé 反应合成：环芳基咪唑配体库的构建。
Chemistry. 2022 Jan 13;28(3):e202103511. doi: 10.1002/chem.202103511. Epub 2021 Dec 8.
8
Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions.三苯基异腈作为多组分化学中的机理探针：游走于乌吉反应和施特雷克反应之间
Chemistry. 2016 Jun 1;22(23):7837-42. doi: 10.1002/chem.201600285. Epub 2016 Apr 26.
9
Trends in the Synthesis of Antimicrobial Derivatives by using the Gewald, Strecker, and Groebke-Blackburn-Bienaymé (GBB) Reactions.利用格沃尔德（Gewald）、斯特雷克（Strecker）和格罗贝克尔-布莱克本-拜恩梅（Groebke-Blackburn-Bienaymé，GBB）反应合成抗菌衍生物的趋势。
Med Chem. 2024;20(7):663-688. doi: 10.2174/0115734064282699240315042428.
10
The status of isocyanide-based multi-component reactions in Iran (2010-2018).伊朗基于异氰化物的多组分反应的现状（2010-2018 年）。
Mol Divers. 2021 May;25(2):1145-1210. doi: 10.1007/s11030-020-10049-7. Epub 2020 Feb 18.

引用本文的文献

1
New tandem Ugi/intramolecular Diels-Alder reaction based on vinylfuran and 1,3-butadienylfuran derivatives.基于乙烯基呋喃和1,3 - 丁二烯基呋喃衍生物的新型串联乌吉/分子内狄尔斯-阿尔德反应
Beilstein J Org Chem. 2025 Feb 26;21:444-450. doi: 10.3762/bjoc.21.31. eCollection 2025.
2
Generation of multimillion chemical space based on the parallel Groebke-Blackburn-Bienaymé reaction.基于平行格罗布克-布莱克本-比纳梅反应生成数百万化学空间。
Beilstein J Org Chem. 2024 Jul 16;20:1604-1613. doi: 10.3762/bjoc.20.143. eCollection 2024.
3
Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer.重新研究Passerini和Ugi支架作为多步凋亡诱导剂：对caspase 3/7和P53-MDM2信号进行双重调节以阻止乳腺癌
RSC Adv. 2023 Sep 20;13(40):27722-27737. doi: 10.1039/d3ra04029a. eCollection 2023 Sep 18.
4
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs.多组分反应辅助药物发现：一种省时、经济且绿色的方法，可加速抗癌药物的鉴定和优化。
Int J Mol Sci. 2023 Apr 1;24(7):6581. doi: 10.3390/ijms24076581.
5
Isocyanide-Based Multicomponent Reactions in Water: Advanced Green Tools for the Synthesis of Heterocyclic Compounds.基于异氰化物的多组分反应在水中：杂环化合物合成的先进绿色工具。
Top Curr Chem (Cham). 2022 Sep 22;380(6):50. doi: 10.1007/s41061-022-00403-8.
6
A trustworthy mechanochemical route to isocyanides.一种可靠的制备异腈的机械化学方法。
Beilstein J Org Chem. 2022 Jun 22;18:732-737. doi: 10.3762/bjoc.18.73. eCollection 2022.
7
Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders.设计、合成及生物评价 1,5-取代-α-氨基四唑衍生物作为非共价型炎症小体-caspase-1 复合物抑制剂用于治疗免疫和炎症性疾病的应用潜力。
Eur J Med Chem. 2022 Feb 5;229:114002. doi: 10.1016/j.ejmech.2021.114002. Epub 2021 Nov 18.
8
Synthesis of 6-Membered-Ring Fused Thiazine-Dicarboxylates and Thiazole-Pyrimidines via One-Pot Three-Component Reactions.一锅法三组分反应合成 6-元环稠合噻嗪-二羧酸酯和噻唑-嘧啶
Molecules. 2021 Sep 10;26(18):5493. doi: 10.3390/molecules26185493.
9
Novel magnetic propylsulfonic acid-anchored isocyanurate-based periodic mesoporous organosilica (Iron oxide@PMO-ICS-PrSOH) as a highly efficient and reusable nanoreactor for the sustainable synthesis of imidazopyrimidine derivatives.新型磁性丙磺酸基笼型倍半硅氧烷基有机硅（氧化亚铁@PMO-ICS-PrSOH）作为高效可重复使用的纳米反应器，用于可持续合成咪唑并嘧啶衍生物。
Sci Rep. 2020 Jun 30;10(1):10646. doi: 10.1038/s41598-020-67592-4.

本文引用的文献

1
Tetrazoles via Multicomponent Reactions.四唑类化合物的多组分反应合成法。
Chem Rev. 2019 Feb 13;119(3):1970-2042. doi: 10.1021/acs.chemrev.8b00564. Epub 2019 Feb 1.
2
Materials Functionalization with Multicomponent Reactions: State of the Art.多组分反应在材料功能化中的应用：最新进展。
ACS Comb Sci. 2018 Sep 10;20(9):499-528. doi: 10.1021/acscombsci.8b00072. Epub 2018 Aug 27.
3
A New Heterocyclic Multicomponent Reaction For the Combinatorial Synthesis of Fused 3-Aminoimidazoles.一种用于组合合成稠合 3-氨基咪唑的新型杂环多组分反应。
Angew Chem Int Ed Engl. 1998 Sep 4;37(16):2234-2237. doi: 10.1002/(SICI)1521-3773(19980904)37:16<2234::AID-ANIE2234>3.0.CO;2-R.
4
Multicomponent reactions provide key molecules for secret communication.多组分反应为秘密通讯提供关键分子。
Nat Commun. 2018 Apr 12;9(1):1439. doi: 10.1038/s41467-018-03784-x.
5
Synthesis of Structurally Diverse Emissive Molecular Rotors with Four-Component Ugi Stators.四组分 Ugi 定子合成结构多样的发光分子转子。
J Org Chem. 2018 Mar 2;83(5):2570-2581. doi: 10.1021/acs.joc.7b02858. Epub 2018 Feb 22.
6
Rational Design of Polymeric Nanoparticles with Tailorable Biomedical Functions for Cancer Therapy.聚合物纳米粒子的合理设计具有可定制的生物医学功能，可用于癌症治疗。
ACS Appl Mater Interfaces. 2017 Sep 6;9(35):29612-29622. doi: 10.1021/acsami.7b10763. Epub 2017 Aug 24.
7
Alternative Affinity Ligands for Immunoglobulins.免疫球蛋白的替代亲和配体
Bioconjug Chem. 2017 Aug 16;28(8):2009-2030. doi: 10.1021/acs.bioconjchem.7b00335. Epub 2017 Jul 20.
8
An Update on Isocyanide-Based Multicomponent Reactions in Polymer Science.异氰化物基多组分反应在聚合科学中的最新进展。
Top Curr Chem (Cham). 2017 Aug;375(4):66. doi: 10.1007/s41061-017-0153-4. Epub 2017 Jun 12.
9
Multicomponent Reactions, Union of MCRs and Beyond.多组分反应，MCR 的联合及超越。
Chem Rec. 2015 Oct;15(5):981-96. doi: 10.1002/tcr.201500201. Epub 2015 Sep 11.
10
Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.绘制人类细胞中完全功能化小分子探针的蛋白质相互作用图谱。
J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.