Yang Huihui, Huang Kaiyao
Key Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Institute of Hydrobiology, University of Chinese Academy of Sciences, Beijing, China.
Front Cell Dev Biol. 2020 Jan 15;7:352. doi: 10.3389/fcell.2019.00352. eCollection 2019.
Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to-intracellular signal integration. To date, in addition to its well-established and indispensable roles in ciliated cells, most IFT subunits have presented more general functions of vesicular trafficking in the non-ciliated cells. Thus, this review aims to summarize the recent progress on the vesicular trafficking functions of the IFT subunits and to highlight the issues that may arise in future research.
鞭毛内运输（IFT）最初被确定为一种具有多个蛋白质亚基的运输机制，它对于纤毛/鞭毛的组装、拆卸和维持至关重要，而纤毛/鞭毛是细胞外到细胞内信号整合的枢纽。迄今为止，除了在纤毛细胞中已确立的不可或缺的作用外，大多数IFT亚基在非纤毛细胞中还呈现出更普遍的囊泡运输功能。因此，本综述旨在总结IFT亚基囊泡运输功能的最新进展，并突出未来研究中可能出现的问题。
