Department of Life Sciences, University of Siena, 53100 Siena, Italy.
Int J Mol Sci. 2022 Oct 12;23(20):12147. doi: 10.3390/ijms232012147.
Initially discovered as the smallest component of the intraflagellar transport (IFT) system, the IFT20 protein has been found to be implicated in several unconventional mechanisms beyond its essential role in the assembly and maintenance of the primary cilium. IFT20 is now considered a key player not only in ciliogenesis but also in vesicular trafficking of membrane receptors and signaling proteins. Moreover, its ability to associate with a wide array of interacting partners in a cell-type specific manner has expanded the function of IFT20 to the regulation of intracellular degradative and secretory pathways. In this review, we will present an overview of the multifaceted role of IFT20 in both ciliated and non-ciliated cells.
最初被发现作为鞭毛内运输 (IFT) 系统的最小组成部分，IFT20 蛋白已被发现涉及几种非常规机制，超出了其在初级纤毛组装和维持中的基本作用。IFT20 现在不仅被认为是纤毛发生的关键参与者，而且也是膜受体和信号蛋白的囊泡运输的关键参与者。此外，IFT20 以细胞类型特异性的方式与广泛的相互作用伙伴结合的能力，将 IFT20 的功能扩展到细胞内降解和分泌途径的调节。在这篇综述中，我们将介绍 IFT20 在有纤毛和无纤毛细胞中的多方面作用。
