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初级纤毛膜组装研究的最新进展。

Recent advances in understanding assembly of the primary cilium membrane.

作者信息

Shakya Saurabh, Westlake Christopher J

机构信息

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Laboratory of Cellular and Developmental Signaling, Frederick, MD 21702, USA.

出版信息

Fac Rev. 2021 Feb 22;10:16. doi: 10.12703/r/10-16. eCollection 2021.

Abstract

Ciliogenesis describes the assembly of cilia in interphase cells. Several hundred proteins have been linked to ciliogenesis, which proceeds through a highly coordinated multistage process at the distal end of centrioles requiring membranes. In this short review, we focus on recently reported insights into the biogenesis of the primary cilium membrane and its association with other ciliogenic processes in the intracellular ciliogenesis pathway.

摘要

纤毛发生描述了间期细胞中纤毛的组装过程。已有数百种蛋白质与纤毛发生相关,纤毛发生是在需要膜的中心粒远端通过高度协调的多阶段过程进行的。在这篇简短的综述中,我们重点关注最近报道的关于初级纤毛膜生物发生及其在细胞内纤毛发生途径中与其他纤毛生成过程关联的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e74f/7946393/49fda9073916/facrev-10-16-g001.jpg

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