Institute of Biochemistry and Cell Biology, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.
Biochem Soc Trans. 2020 Feb 28;48(1):245-256. doi: 10.1042/BST20190646.
The Golgi complex (GC) has an essential role in the processing and sorting of proteins and lipids. The GC of mammalian cells is composed of stacks of cisternae connected by membranous tubules to create a continuous network, the Golgi ribbon, whose maintenance requires several core and accessory proteins. Despite this complex structural organization, the Golgi apparatus is highly dynamic, and this property becomes particularly evident during mitosis, when the ribbon undergoes a multistep disassembly process that allows its correct partitioning and inheritance by the daughter cells. Importantly, alterations of the Golgi structure are associated with a variety of physiological and pathological conditions. Here, we review the core mechanisms and signaling pathways involved in both the maintenance and disassembly of the Golgi ribbon, and we also report on the signaling pathways that connect the disassembly of the Golgi ribbon to mitotic entry and progression.
高尔基复合体（GC）在蛋白质和脂质的加工和分拣中具有重要作用。哺乳动物细胞的 GC 由堆叠的潴泡通过膜小管连接而成，形成一个连续的网络，即高尔基带，其维持需要几种核心蛋白和辅助蛋白。尽管具有这种复杂的结构组织，高尔基器仍然具有高度的动态性，这种特性在有丝分裂期间变得尤为明显，此时带经历一个多步骤的解体过程，允许其正确分配和遗传给子细胞。重要的是，高尔基结构的改变与多种生理和病理状况有关。在这里，我们综述了维持和解体高尔基带的核心机制和信号通路，并报告了将高尔基带的解体与有丝分裂进入和进展联系起来的信号通路。
